Classical CD4 T cells as the cornerstone of antimycobacterial immunity.
CD4 T cells
Mtb-specific T cells
TB
mycobacteria
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
11
02
2021
received:
06
01
2021
accepted:
13
02
2021
pubmed:
23
3
2021
medline:
26
10
2021
entrez:
22
3
2021
Statut:
ppublish
Résumé
Tuberculosis is a significant health problem without an effective vaccine to combat it. A thorough understanding of the immune response and correlates of protection is needed to develop a more efficient vaccine. The immune response against Mycobacterium tuberculosis (Mtb) is complex and involves all aspects of the immune system, however, the optimal protective, non-pathogenic T cell response against Mtb is still elusive. This review will focus on discussing CD4 T cell immunity against mycobacteria and its importance in Mtb infection with a primary focus on human studies. We will in particular discuss the large heterogeneity of immune cell subsets that have been revealed by recent immunological investigations at an unprecedented level of detail. These studies have identified specific classical CD4 T cell subsets important for immune responses against Mtb in various states of infection. We further discuss the functional attributes that have been linked to the various subsets such as upregulation of activation markers and cytokine production. Another important topic to be considered is the antigenic targets of Mtb-specific immune responses, and how antigen reactivity is influenced by both disease state and environmental exposure(s). These are key points for both vaccines and immune diagnostics development. Ultimately, these factors are holistically considered in the definition and investigations of what are the correlates on protection and resolution of disease.
Identifiants
pubmed: 33751597
doi: 10.1111/imr.12963
pmc: PMC8252593
doi:
Substances chimiques
Antigens, Bacterial
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-29Subventions
Organisme : NIAID NIH HHS
ID : 75N93019C00067
Pays : United States
Informations de copyright
© 2021 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
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