On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity.

Animals Antineoplastic Agents / pharmacology Cell Line, Tumor Cisplatin Drug Resistance, Neoplasm Female Humans Mice Mice, Nude Ovarian Neoplasms / drug therapy Spectrum Analysis, Raman Sulfides
3-Mercaptopyruvate sulfotransferase Ambroxol Cancer stroma Imaging metabolomics

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
05 2021
Historique:
received: 26 01 2021
revised: 23 02 2021
accepted: 26 02 2021
pubmed: 23 3 2021
medline: 6 7 2021
entrez: 22 3 2021
Statut: ppublish

Résumé

Chemosensitivity to cisplatin derivatives varies among individual patients with intractable malignancies including ovarian cancer, while how to unlock the resistance remain unknown. Ovarian cancer tissues were collected the debulking surgery in discovery- (n = 135) and validation- (n = 47) cohorts, to be analyzed with high-throughput automated immunohistochemistry which identified cystathionine γ-lyase (CSE) as an independent marker distinguishing non-responders from responders to post-operative platinum-based chemotherapy. We aimed to identify CSE-derived metabolites responsible for chemoresistant mechanisms: gold-nanoparticle (AuN)-based surface-enhanced Raman spectroscopy (SERS) was used to enhance electromagnetic fields which enabled to visualize multiple sulfur-containing metabolites through detecting scattering light from Au-S vibration two-dimensionally. Clear cell carcinoma (CCC) who turned out less sensitive to cisplatin than serous adenocarcinoma was classified into two groups by the intensities of SERS intensities at 480 cm

Identifiants

DOI: 10.1016/j.redox.2021.101926 PMID: 33752108 PMC: PMC8010883
pubmed: 33752108
pii: S2213-2317(21)00074-4
doi: 10.1016/j.redox.2021.101926
pmc: PMC8010883
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Sulfides 0
polysulfide 9080-49-3
Cisplatin Q20Q21Q62J

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101926

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Kazufumi Honda (K)

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan; AMED-CREST, Japan Agency for Medical Research and Development (AMED), Japan; Department of Bioregulation, Graduate School of Medicine, Nippon Medical School, Japan.

Takako Hishiki (T)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Sohei Yamamoto (S)

Department of Diagnostic Pathology, Anjo Kosei Hospital, Aichi, Japan.

Takehiro Yamamoto (T)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Nami Miura (N)

Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, Tokyo, Japan; Department of Bioregulation, Graduate School of Medicine, Nippon Medical School, Japan.

Akiko Kubo (A)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Mai Itoh (M)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Wei-Yu Chen (WY)

Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Masashi Takano (M)

Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan.

Tomoyuki Yoshikawa (T)

Department of Clinical Oncology, National Defense Medical College Hospital, Saitama, Japan.

Takahiro Kasamatsu (T)

Department of Obstetrics and Gynecology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.

Shinichiro Sonoda (S)

Frontier Core Technology Laboratories, R&D Management Headquarters, FUJIFILM Corporation, Ashigara-gun, Kanagawa, Japan.

Hirotoshi Yoshizawa (H)

Frontier Core Technology Laboratories, R&D Management Headquarters, FUJIFILM Corporation, Ashigara-gun, Kanagawa, Japan.

Seigo Nakamura (S)

Frontier Core Technology Laboratories, R&D Management Headquarters, FUJIFILM Corporation, Ashigara-gun, Kanagawa, Japan.

Yuichiro Itai (Y)

Frontier Core Technology Laboratories, R&D Management Headquarters, FUJIFILM Corporation, Ashigara-gun, Kanagawa, Japan.

Megumi Shiota (M)

Frontier Core Technology Laboratories, R&D Management Headquarters, FUJIFILM Corporation, Ashigara-gun, Kanagawa, Japan.

Daisuke Koike (D)

FUJIFILM Business Expert Corporation, Ashigara-gun, Kanagawa, Japan.

Masayuki Naya (M)

Frontier Core Technology Laboratories, R&D Management Headquarters, FUJIFILM Corporation, Ashigara-gun, Kanagawa, Japan.

Noriyo Hayakawa (N)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Yoshiko Naito (Y)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Tomomi Matsuura (T)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan.

Keiko Iwaisako (K)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University, 54 Shogoin kawaracho, Sakyo, Kyoto, Japan; Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe city, Kyoto, Japan.

Toshihiko Masui (T)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University, 54 Shogoin kawaracho, Sakyo, Kyoto, Japan.

Shinji Uemoto (S)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University, 54 Shogoin kawaracho, Sakyo, Kyoto, Japan.

Kengo Nagashima (K)

Research Center for Medical and Health Data Science, The Institute of Statistical Mathematics, Tokyo, Japan.

Yoshinori Hashimoto (Y)

Scientific Imaging Scanner Department, System Division, Hamamatsu Photonics, Hamamatsu, Japan.

Tomohiro Sakuma (T)

Bioscience Division, Mitsui Knowledge Industry Corporation, Ltd., Tokyo, Japan.

Osamu Matsubara (O)

Department of Pathology, Hiratsuka Kyosai Hospital, The Cancer Institute, Kanagawa, Japan.

Wilber Huang (W)

Abnova Corporation, Taipei, Taiwan.

Tomoaki Ida (T)

Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Takaaki Akaike (T)

Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Yohei Masugi (Y)

Department of Pathology, Keio University School of Medicine, Japan.

Michiie Sakamoto (M)

Department of Pathology, Keio University School of Medicine, Japan.

Tomoyasu Kato (T)

Division of Gynecology, National Cancer Center Hospital, Tokyo, Japan.

Yoshinori Ino (Y)

Division of Molecular Pathology, National Cancer Center Research Institute, Japan.

Hiroshi Yoshida (H)

Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.

Hitoshi Tsuda (H)

Department of Basic Pathology, National Defense Medical College, Saitama, Japan.

Nobuyoshi Hiraoka (N)

Division of Molecular Pathology, National Cancer Center Research Institute, Japan; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.

Yasuaki Kabe (Y)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan; AMED-CREST, Japan Agency for Medical Research and Development (AMED), Japan.

Makoto Suematsu (M)

Department Biochemistry, Keio University School of Medicine, Tokyo, Japan. Electronic address: gasbiology@keio.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › On-tissue polysulfide visualization by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › On-tissue polysulfide visualization by...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › On-tissue polysulfide visualization by...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du platine › Cisplatine › On-tissue polysulfide visualization by...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › On-tissue polysulfide visualization by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › On-tissue polysulfide visualization by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › On-tissue polysulfide visualization by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › On-tissue polysulfide visualization by...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › On-tissue polysulfide visualization by...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Analyse spectrale Raman › On-tissue polysulfide visualization by...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › On-tissue polysulfide visualization by...