Withanolides isolated from Tubocapsicum anomalum and their antiproliferative activity.
Antineoplastic Agents, Phytogenic
/ chemistry
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Plant Extracts
/ chemistry
Solanaceae
/ chemistry
Structure-Activity Relationship
Tumor Cells, Cultured
Withanolides
/ chemistry
Antiproliferative activities
Tubocapsicum anomalum
Withanolides
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
06
02
2021
revised:
01
03
2021
accepted:
03
03
2021
pubmed:
23
3
2021
medline:
13
10
2021
entrez:
22
3
2021
Statut:
ppublish
Résumé
Seven undescribed withanolides (1-7) and six artificial withanolides (8-13), along with 20 known compounds (14-33) were isolated from the aerial parts of Tubocapsicum anomalum. Their structures were confirmed by comprehensive spectroscopic analyses. The absolute configuration of compound 1 was defined by single-crystal X-ray crystallography. All isolates were evaluated for their antiproliferative effects against five human tumor cell lines (Hep3B, MDA-MB-231, SW480, HCT116 and A549), among which compound 24 (tubocapsanolide A) exhibited the highest activities against the MDA-MB-231 cells with an IC
Identifiants
pubmed: 33752145
pii: S0045-2068(21)00186-3
doi: 10.1016/j.bioorg.2021.104809
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Plant Extracts
0
Withanolides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104809Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.