Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics.
Alzheimer's disease
Huntington's disease
Parkinson's disease
autophagy
neurodegenerative disease
Journal
Clinical and experimental pharmacology & physiology
ISSN: 1440-1681
Titre abrégé: Clin Exp Pharmacol Physiol
Pays: Australia
ID NLM: 0425076
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
17
03
2021
received:
12
01
2021
accepted:
18
03
2021
pubmed:
23
3
2021
medline:
7
1
2022
entrez:
22
3
2021
Statut:
ppublish
Résumé
Many neurodegenerative diseases are associated with pathological aggregation of proteins in neurons. Autophagy is a natural self-cannibalization process that can act as a powerful mechanism to remove aged and damaged organelles as well as protein aggregates. It has been shown that promoting autophagy can attenuate or delay neurodegeneration by removing protein aggregates. In this paper, we will review the role of autophagy in Alzheimer's disease (AD), Parkinson's Disease (PD), and Huntington's Disease (HD) and discuss opportunities and challenges of targeting autophagy as a potential therapeutic avenue for treatment of these common neurodegenerative diseases.
Identifiants
pubmed: 33752254
doi: 10.1111/1440-1681.13500
pmc: PMC8204470
mid: NIHMS1708484
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
943-953Subventions
Organisme : NINDS NIH HHS
ID : K08 NS091499
Pays : United States
Informations de copyright
© 2021 John Wiley & Sons Australia, Ltd.
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