Hepatorenal Syndrome.

Acute Kidney Injury / diagnosis Creatinine Hepatorenal Syndrome / diagnosis Humans Hypertension, Portal / diagnosis Liver Cirrhosis
Acute kidney injury Acute on chronic liver failure Biomarkers Cirrhosis Hepatorenal syndrome Liver transplantation Model end-stage liver disease Simultaneous liver kidney transplantation

Journal

Critical care clinics
ISSN: 1557-8232
Titre abrégé: Crit Care Clin
Pays: United States
ID NLM: 8507720

Informations de publication

Date de publication:
Apr 2021
Historique:
entrez: 23 3 2021
pubmed: 24 3 2021
medline: 19 8 2021
Statut: ppublish

Résumé

Development of acute kidney injury in patients with chronic liver disease is common and portends a poor prognosis. Diagnosis remains challenging, as traditional markers, such as serum creatinine, are not reliable. Recent development of novel biomarkers may assist with this. Pathophysiology of this condition is multifactorial, relating to physiologic changes associated with portal hypertension, kidney factors, and systemic inflammatory response. Mainstay of treatment remains use of vasoconstrictors along with albumin. Recent guidelines streamline the selection of patients that will require simultaneous liver and kidney transplantation. Posttransplant kidney injury is common relating to multiple factors.

Identifiants

DOI: 10.1016/j.ccc.2020.11.011 PMID: 33752858
pubmed: 33752858
pii: S0749-0704(20)30116-0
doi: 10.1016/j.ccc.2020.11.011
pii:
doi:

Substances chimiques

Creatinine AYI8EX34EU

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

321-334

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure All authors: none.

Auteurs

Saro Khemichian (S)

Division of Gastroenterology/Liver, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA.

Claire Francoz (C)

Hepatology and Liver Intensive Care, Hospital Beaujon, 100 Boulevard Du General Leclerc, Clichy 92110, France.

Francois Durand (F)

Hepatology and Liver Intensive Care, Hospital Beaujon, University of Paris, 100 Boulevard Du General Leclerc, Clichy 92110, France.

Constantine J Karvellas (CJ)

Division of Gastroenterology (Liver Unit), Department of Critical Care Medicine, University of Alberta, 1-40 Zeidler Ledcor Building, Edmonton, Alberta T6G 2X8, Canada.

Mitra K Nadim (MK)

Division of Nephrology and Hypertension, Keck School of Medicine, University of Southern California, 1520 San Pablo Street, Suite 4300, Los Angeles, CA 90033, USA. Electronic address: mitra.nadim@med.usc.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Hepatorenal Syndrome.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Créatinine › Hepatorenal Syndrome.
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Syndrome hépatorénal › Hepatorenal Syndrome.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hepatorenal Syndrome.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Hypertension portale › Hepatorenal Syndrome.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Hepatorenal Syndrome.