Optical signatures of radiofrequency ablation in biological tissues.

Biomarkers Optical Imaging / methods Organ Specificity Radiofrequency Ablation / methods Scattering, Radiation Spectrum Analysis / methods Temperature

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
22 03 2021
Historique:
received: 19 10 2020
accepted: 02 03 2021
entrez: 23 3 2021
pubmed: 24 3 2021
medline: 26 10 2021
Statut: epublish

Résumé

Accurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in oncology and cardiovascular disease. We investigated alterations in optical properties of ex-vivo bovine tissues of the liver, heart, muscle, and brain, undergoing the treatment. Time-domain diffuse optical spectroscopy was used, which enabled us to disentangle and quantify absorption and reduced scattering spectra. In addition to the well-known global (1) decrease in absorption, and (2) increase in reduced scattering, we uncovered new features based on sensitive detection of spectral changes. These absorption spectrum features are: (3) emergence of a peak around 840 nm, (4) redshift of the 760 nm deoxyhemoglobin peak, and (5) blueshift of the 970 nm water peak. Treatment temperatures above 100 °C led to (6) increased absorption at shorter wavelengths, and (7) further decrease in reduced scattering. This optical behavior provides new insights into tissue response to thermal treatment and sets the stage for optical monitoring of radiofrequency ablation.

Identifiants

DOI: 10.1038/s41598-021-85653-0 PMID: 33753778 PMC: PMC7985316
pubmed: 33753778
doi: 10.1038/s41598-021-85653-0
pii: 10.1038/s41598-021-85653-0
pmc: PMC7985316
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6579

Commentaires et corrections

Type : ErratumIn

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Auteurs

Pranav Lanka (P)

Department of Physics, Politecnico di Milano, Milan, Italy.

Kalloor Joseph Francis (KJ)

Multi-Modality Medical Imaging Group, University of Twente, Enschede, The Netherlands.
Biomedical Photonic Imaging Group Technical Medical Centre, University of Twente, Enschede, The Netherlands.

Hindrik Kruit (H)

Multi-Modality Medical Imaging Group, University of Twente, Enschede, The Netherlands.

Andrea Farina (A)

Institute of Photonics and Nanotechnologies, National Research Council, Milan, Italy. andrea.farina@cnr.it.

Rinaldo Cubeddu (R)

Department of Physics, Politecnico di Milano, Milan, Italy.

Sanathana Konugolu Venkata Sekar (SKV)

Biophotonics@Tyndall, IPIC, Tyndall National Institute, Lee Maltings, Dyke Parade, Cork, Ireland.

Srirang Manohar (S)

Multi-Modality Medical Imaging Group, University of Twente, Enschede, The Netherlands.

Antonio Pifferi (A)

Department of Physics, Politecnico di Milano, Milan, Italy.
Institute of Photonics and Nanotechnologies, National Research Council, Milan, Italy.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Optical signatures of radiofrequency ablation...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Optical signatures of radiofrequency ablation...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Optical signatures of radiofrequency ablation...
questionsmedicales.fr › Procédures de chirurgie opératoire › Techniques d'ablation › Ablation par radiofréquence › Optical signatures of radiofrequency ablation...
questionsmedicales.fr › Phénomènes physiques › Diffusion de rayonnements › Optical signatures of radiofrequency ablation...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Optical signatures of radiofrequency ablation...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Optical signatures of radiofrequency ablation...