Serum levels of vitamin D in patients with recurrent aphthous stomatitis.
immune system
recurrent aphthous stomatitis
vitamin D
Journal
Dental and medical problems
ISSN: 2300-9020
Titre abrégé: Dent Med Probl
Pays: Poland
ID NLM: 101205669
Informations de publication
Date de publication:
Historique:
pubmed:
24
3
2021
medline:
8
6
2021
entrez:
23
3
2021
Statut:
ppublish
Résumé
Recurrent aphthous stomatitis (RAS) is one of the most common recurrent ulcerations in the oral mucosa, the etiology of which has not been elucidated; the immune system dysfunction may play an important role in the pathogenesis of RAS. The anti-inflammatory and regulatory role of vitamin D in the functioning of the immune system is well-documented. This study aimed to evaluate and compare the serum levels of vitamin D between patients with RAS and healthy controls. In this case-control study, 43 patients with minor RAS and 43 healthy controls were included. Two groups were matched in terms of age and sex. Blood samples were obtained from all participants. The serum levels of vitamin D were measured with the use of the enzyme-linked immunosorbent assay (ELISA) in patient and control groups. The data was analyzed using the SPSS for Windows software, v. 17.0, with the independent samples t test and the Mann-Whitney test. A p-value of <0.05 was considered statistically significant. The mean serum level of vitamin D in the control group was significantly higher than that in the case group (22.59 ±16.06 ng/mL vs 13.19 ±8.19 ng/mL, respectively; p = 0.002). The serum levels of vitamin D are lower in patients with RAS in comparison with healthy controls.
Sections du résumé
BACKGROUND
Recurrent aphthous stomatitis (RAS) is one of the most common recurrent ulcerations in the oral mucosa, the etiology of which has not been elucidated; the immune system dysfunction may play an important role in the pathogenesis of RAS. The anti-inflammatory and regulatory role of vitamin D in the functioning of the immune system is well-documented.
OBJECTIVES
This study aimed to evaluate and compare the serum levels of vitamin D between patients with RAS and healthy controls.
MATERIAL AND METHODS
In this case-control study, 43 patients with minor RAS and 43 healthy controls were included. Two groups were matched in terms of age and sex. Blood samples were obtained from all participants. The serum levels of vitamin D were measured with the use of the enzyme-linked immunosorbent assay (ELISA) in patient and control groups. The data was analyzed using the SPSS for Windows software, v. 17.0, with the independent samples t test and the Mann-Whitney test. A p-value of <0.05 was considered statistically significant.
RESULTS
The mean serum level of vitamin D in the control group was significantly higher than that in the case group (22.59 ±16.06 ng/mL vs 13.19 ±8.19 ng/mL, respectively; p = 0.002).
CONCLUSIONS
The serum levels of vitamin D are lower in patients with RAS in comparison with healthy controls.
Substances chimiques
Vitamins
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM