Loss of putative GABAergic neurons in the ventrolateral medulla in multiple system atrophy.
Lateral paragigantocellular nucleus
REM sleep
alpha-synuclein
autonomic
cardiovagal multiple system atrophy
orthostatic hypotension
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
13 09 2021
13 09 2021
Historique:
received:
08
12
2020
revised:
17
03
2021
pubmed:
24
3
2021
medline:
30
10
2021
entrez:
23
3
2021
Statut:
ppublish
Résumé
Multiple system atrophy (MSA) is associated with disturbances in cardiovascular, sleep and respiratory control. The lateral paragigantocellular nucleus (LPGi) in the ventrolateral medulla (VLM) contains GABAergic neurons that participate in control of rapid eye movement (REM) sleep and cardiovagal responses. We sought to determine whether there was loss of putative GABAergic neurons in the LPGi and adjacent regions in MSA. Sections of the medulla were processed for GAD65/67 immunoreactivity in eight subjects with clinical and neuropathological diagnosis of MSA and in six control subjects. These putative GABAergic LPGi neurons were mapped based on their relationship to adjacent monoaminergic VLM groups. There were markedly decreased numbers of GAD-immunoreactive neurons in the LPGi and adjacent VLM regions in MSA. There is loss of GABAergic neurons in the VLM, including the LPGi in patients with MSA. Whereas these findings provide a possible mechanistic substrate, given the few cases included, further studies are necessary to determine whether they contribute to REM sleep-related cardiovagal and possibly respiratory dysregulation in MSA.
Identifiants
pubmed: 33755181
pii: 6182442
doi: 10.1093/sleep/zsab074
pmc: PMC8436134
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : P01 NS044233
Pays : United States
Organisme : FDA HHS
ID : R01 FD004789
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092625
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS065736
Pays : United States
Informations de copyright
© Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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