Antiosteoporosis effect of geraniin on ovariectomy-induced osteoporosis in experimental rats.
antioxidant
bone turnover marker
geraniin
osteoporosis
pro-inflammatory cytokines
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
23
01
2021
received:
01
12
2020
accepted:
12
03
2021
pubmed:
24
3
2021
medline:
28
7
2021
entrez:
23
3
2021
Statut:
ppublish
Résumé
Osteoporosis is a skeletal condition that is characterized by decreasing bone density and deteriorating bone mass. The plant-based phytoconstituent such as geraniin possesses better therapeutic potentials in biomedical field. In the current experimental study, we planned to scrutinize the therapeutic potential of geraniin against ovariectomy (OVX)-induced osteoporosis in rats and find the possible mechanism. Healthy Sprague Dawley rats were randomized into six groups and subjected to geraniin and alendronate (ALN) treatment for 10 weeks. Body weight, uterus, femur weight, bone biochemical, bone turnover markers, inflammatory cytokine, calcium, phosphorus, vitamin D (Vit D), urine, hormones, and antioxidant level were estimated. Geraniin significantly (p < .001) reduced the level of bone turnover markers including beta-CrossLaps (β-CTx), ALN, osteocalcin (OC), alkaline phosphatase (ALP), and bone Gla protein (BGP); reduced the biomechanical parameters including maximum load, energy, stiffness, maximum stress, and Young's modulus; reduced the level of calcium (Ca) and phosphorus (P); and increased the level of vitamin D (Vit D) as compared with OVX-induced osteoporosis rats. Geraniin increased the level of bone structure parameters, namely bone mineral density, bone mineral content, tissue mineral density, bone volume fraction, and trabecular number; increased the level of osteoprotegerin (OPG) and OPG/RANKL; and reduced the level of receptor activator of nuclear factor kappa-Β ligand (RANKL). Geraniin significantly (p < .001) increased the level of glutathione (GSH) and reduced the level of malonaldehyde (MDA) in the liver, intestine, and bone of OVX-induced osteoporosis rats. Geraniin significantly (p < .001) decreased the level of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) pro-inflammatory cytokines. We also argue that geraniin could be an excellent candidate to treat and control bone-related disease or disorders.
Substances chimiques
Glucosides
0
Hydrolyzable Tannins
0
Geraniin
60976-49-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-8Subventions
Organisme : Featured Clinical Discipline Project of Shanghai Pudong New District
ID : Pwyts2018-02
Organisme : Construction of Key Discipline Group of Sanitary System of Shanghai Pudong
ID : PWZxq2017-12
Organisme : The Science and Technology Development and Livelihood Research Fund; Pudong New District, Shanghai, China
ID : PKJ2020-Y44
Informations de copyright
© 2021 Wiley Periodicals LLC.
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