Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus.
Streptococcus
antimicrobial
biofilms
innate immunity
lactoferrin
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
revised:
15
02
2021
received:
12
01
2021
pubmed:
24
3
2021
medline:
29
12
2021
entrez:
23
3
2021
Statut:
ppublish
Résumé
Group B Streptococcus (GBS) is an encapsulated Gram-positive human pathogen that causes invasive infections in pregnant hosts and neonates, as well as immunocompromised individuals. Colonization of the human host requires the ability to adhere to mucosal surfaces and circumnavigate the nutritional challenges and antimicrobial defenses associated with the innate immune response. Biofilm formation is a critical process to facilitate GBS survival and establishment of a replicative niche in the vertebrate host. Previous work has shown that the host responds to GBS infection by producing the innate antimicrobial glycoprotein lactoferrin, which has been implicated in repressing bacterial growth and biofilm formation. Additionally, lactoferrin is highly abundant in human breast milk and could serve a protective role against invasive microbial pathogens. This study demonstrates that human breast milk lactoferrin has antimicrobial and anti-biofilm activity against GBS and inhibits its adherence to human gestational membranes. Together, these results indicate that human milk lactoferrin could be used as a prebiotic chemotherapeutic strategy to limit the impact of bacterial adherence and biofilm formation on GBS-associated disease outcomes.
Identifiants
pubmed: 33755306
doi: 10.1002/cbic.202100016
pmc: PMC8254657
mid: NIHMS1709533
doi:
Substances chimiques
Anti-Bacterial Agents
0
Lactoferrin
EC 3.4.21.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2124-2133Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : National Science Foundation
ID : 1400969
Organisme : NICHD NIH HHS
ID : R01 HD090061
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI112541
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007411
Pays : United States
Organisme : NICHD NIH HHS
ID : F32 HD100087
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024975
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI151100
Pays : United States
Organisme : NCATS NIH HHS
ID : U01 TR002398
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133602
Pays : United States
Organisme : National Science Foundation
ID : 1547757
Organisme : NIAID NIH HHS
ID : R01 AI134036
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
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