Single-trial decoding of movement intentions using functional ultrasound neuroimaging.
Brain-machine interface
Non-human primate
Posterior parietal Cortex
Reach
Saccade
functional ultrasound neuroimaging
movement planning
single-trial decoding
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
05 05 2021
05 05 2021
Historique:
received:
02
07
2020
revised:
29
12
2020
accepted:
01
03
2021
pubmed:
24
3
2021
medline:
12
6
2021
entrez:
23
3
2021
Statut:
ppublish
Résumé
New technologies are key to understanding the dynamic activity of neural circuits and systems in the brain. Here, we show that a minimally invasive approach based on ultrasound can be used to detect the neural correlates of movement planning, including directions and effectors. While non-human primates (NHPs) performed memory-guided movements, we used functional ultrasound (fUS) neuroimaging to record changes in cerebral blood volume with 100 μm resolution. We recorded from outside the dura above the posterior parietal cortex, a brain area important for spatial perception, multisensory integration, and movement planning. We then used fUS signals from the delay period before movement to decode the animals' intended direction and effector. Single-trial decoding is a prerequisite to brain-machine interfaces, a key application that could benefit from this technology. These results are a critical step in the development of neuro-recording and brain interface tools that are less invasive, high resolution, and scalable.
Identifiants
pubmed: 33756104
pii: S0896-6273(21)00151-3
doi: 10.1016/j.neuron.2021.03.003
pmc: PMC8105283
mid: NIHMS1683074
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1554-1566.e4Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM008042
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS099724
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests M.T. is a co-founder and shareholder of Iconeus Company, which commercializes ultrasonic neuroimaging scanners. D.M. is now affiliated with T.U. Delft, Netherlands. V.C. is now affiliated with University of California, Riverside.
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