The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity.
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
28
10
2020
accepted:
24
02
2021
revised:
17
02
2021
pubmed:
25
3
2021
medline:
19
3
2022
entrez:
24
3
2021
Statut:
ppublish
Résumé
Dendritic cell (DC) development is orchestrated by lineage-determining transcription factors (TFs). Although, members of the activator-protein-1 (AP-1) family, including Batf3, have been implicated in conventional (c)DC specification, the role of Jun proteins is poorly understood. Here, we identified c-Jun and JunB as essential for cDC1 fate specification and function. In mice, Jun proteins regulate extrinsic and intrinsic pathways, which control CD8α cDC1 diversification, whereas CD103 cDC1 development is unaffected. The loss of c-Jun and JunB in DC progenitors diminishes the CD8α cDC1 pool and thus confers resistance to Listeria monocytogenes infection. Their absence in CD8α cDC1 results in impaired TLR triggering and antigen cross-presentation. Both TFs are required for the maintenance of the CD8α cDC1 subset and suppression of cDC2 identity on a transcriptional and phenotypic level. Taken together, these results demonstrate the essential role of c-Jun and JunB in CD8α cDC1 diversification, function, and maintenance of their identity.
Identifiants
pubmed: 33758366
doi: 10.1038/s41418-021-00765-4
pii: 10.1038/s41418-021-00765-4
pmc: PMC8329169
doi:
Substances chimiques
JunB protein, mouse
0
Transcription Factor AP-1
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2404-2420Subventions
Organisme : Austrian Science Fund FWF
ID : DOC 32
Pays : Austria
Informations de copyright
© 2021. The Author(s).
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