Low blood caspase-8 levels in survivor patients of traumatic brain injury.
Brain
Caspase-8
Injury
Mortality
Patients
Trauma
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
02
12
2020
accepted:
18
03
2021
pubmed:
25
3
2021
medline:
15
12
2021
entrez:
24
3
2021
Statut:
ppublish
Résumé
High concentrations of caspase-8 (main initiator caspase of the extrinsic pathway of apoptosis) have been found in brain tissue of patients with traumatic brain injury (TBI) and in the blood of patients with different diseases. However, blood caspase-8 concentrations in TBI patients have not been reported. Therefore, our aim was to analyze whether blood caspase-8 concentrations are associated with mortality in TBI patients. Patients with isolated and severe TBI were included. TBI was considered isolated if it showed an Injury Severity Score (ISS) <10 points on non-cranial aspects. TBI was considered severe if it showed a Glasgow Coma Scale (GCS) <9 points. This prospective observational study was conducted in 5 Intensive Care Units. Serum caspase-8 concentrations were measured on day 1 of TBI. Surviving patients (n=59) had lower age (p=0.004), higher GCS (p=0.001), lower APACHE-II score (p<0.001), lower high-risk-of-death computed tomography (CT) findings (p=0.02), lower intracranial pressure (ICP) (p=0.01), and lower serum caspase-8 concentrations (p<0.001) than non-surviving patients (n=24). An association was found between serum caspase-8 levels and mortality after controlling for CT findings, GCS, and age (OR=1.037; 95% CI=1.013-1.062; p=0.002), and after controlling for CT findings, APACHE-II, and ICP (OR=1.042; 95% CI=1.013-1.071; p=0.004) in multiple logistic regression. To our knowledge, this is the first series describing blood caspase-8 concentrations in patients with TBI. The association of high blood caspase-8 concentrations with mortality was the main new finding of the study. However, further investigations are needed to validate the preliminary results of our study.
Identifiants
pubmed: 33759054
doi: 10.1007/s10072-021-05205-2
pii: 10.1007/s10072-021-05205-2
doi:
Substances chimiques
Caspase 8
EC 3.4.22.-
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
5065-5070Subventions
Organisme : Instituto de Salud Carlos III (ES)
ID : PI-18-00500
Informations de copyright
© 2021. Fondazione Società Italiana di Neurologia.
Références
Brain Trauma Foundation, American Association of Neurological Surgeons, Congress of Neurological Surgeons (2007) Guidelines for the management of severe traumatic brain injury. J Neurotrauma 24:S1–S106
doi: 10.1089/neu.2007.9997
Zhang X, Chen Y, Jenkins LW, Kochanek PM, Clark RS (2005) Bench-to-bedside review: apoptosis/programmed cell death triggered by traumatic brain injury. Crit Care 9(1):66–75. https://doi.org/10.1186/cc2950
doi: 10.1186/cc2950
pubmed: 15693986
Kunz A, Dirnagl U, Mergenthaler P (2010) Acute pathophysiological processes after ischaemic and traumatic brain injury. Best Pract Res Clin Anaesthesiol 24:495–509
doi: 10.1016/j.bpa.2010.10.001
Cavallucci V, D'Amelio M (2011) Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases. Curr Pharm Des 17:215–229
doi: 10.2174/138161211795049705
Wang K, Liu B, Ma J (2014) Research progress in traumatic brain penumbra. Chin Med J 127:1964–1968
pubmed: 24824264
Rovegno M, Soto PA, Sáez JC, von Bernhardi R (2012) Biological mechanisms involved in the spread of traumatic brain damage. Med Intensiva 36:37–44
doi: 10.1016/j.medin.2011.06.008
Glushakova OY, Glushakov AA, Wijesinghe DS, Valadka AB, Hayes RL, Glushakov AV (2017) Prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: implications for chronic neurodegeneration. Brain Circ 3(2):87–108. https://doi.org/10.4103/bc.bc_27_16
doi: 10.4103/bc.bc_27_16
pubmed: 30276309
pmcid: 6126261
Ng I, Yeo TT, Tang WY, Soong R, Ng PY, Smith DR (2000) Apoptosis occurs after cerebral contusions in humans. Neurosurgery. 46:949–956
pubmed: 10764270
Smith FM, Raghupathi R, MacKinnon MA, McIntosh TK, Saatman KE, Meaney DF, Graham DI (2000) TUNEL-positive staining of surface contusions after fatal head injury in man. Acta Neuropathol 100:537–545
doi: 10.1007/s004010000222
Shaw K, MacKinnon MA, Raghupathi R, Saatman KE, Mclntosh TK, Graham DI (2001) TUNEL-positive staining in white and grey matter after fatal head injury in man. Clin Neuropathol 20:106–112
pubmed: 11430493
Williams S, Raghupathi R, MacKinnon MA, McIntosh TK, Saatman KE, Graham DI (2001) In situ DNA fragmentation occurs in white matter up to 12 months after head injury in man. Acta Neuropathol 102:581–590
doi: 10.1007/s004010100410
Miñambres E, Ballesteros MA, Mayorga M, Marin MJ, Muñoz P, Figols J, López-Hoyos M (2008) Cerebral apoptosis in severe traumatic brain injury patients: an in vitro, in vivo, and postmortem study. J Neurotrauma 25:581–591
doi: 10.1089/neu.2007.0398
Flygt J, Gumucio A, Ingelsson M, Skoglund K, Holm J, Alafuzoff I, Marklund N (2016) Human traumatic brain injury results in oligodendrocyte death and increases the number of oligodendrocyte progenitor cells. J Neuropathol Exp Neurol 75:503–515
doi: 10.1093/jnen/nlw025
Zhang X, Graham SH, Kochanek PM, Marion DW, Nathaniel PD, Watkins SC, Clark RS (2003) Caspase-8 expression and proteolysis in human brain after severe head injury. FASEB J 17(10):1367–1369. https://doi.org/10.1096/fj.02-1067fje
doi: 10.1096/fj.02-1067fje
pubmed: 12738800
Yang X, Sun B, Wang H, Yin C, Wang X, Ji X (2015) Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling. J Biomed Res 29:232–240
pubmed: 26060447
Petrackova A, Smrzova A, Gajdos P, Schubertova M, Schneiderova P, Kromer P, Snasel V, Skacelova M, Mrazek F, Zadrazil J, Horak P, Kriegova E (2017) Serum protein pattern associated with organ damage and lupus nephritis in systemic lupus erythematosus revealed by PEA immunoassay. Clin Proteomics 14:32
doi: 10.1186/s12014-017-9167-8
Drapkina OM, Deeva TA, Ivashkin VT (2015) Evaluation of endothelial function and estimation of the degree of apoptosis in patients with metabolic syndrome and non-alcoholic fatty liver disease. Ter Arkh 87:76–83
doi: 10.17116/terarkh201587576-83
Lorente L, Martín MM, Ortiz-López R, González-Rivero AF, Pérez-Cejas A, Martín M, Gonzalez V, Pérez A, Rodin M, Jiménez A (2020) Blood caspase-8 concentrations and mortality among septic patients. Med Intensiva S0210-5691(20):30246–30241. English, Spanish. https://doi.org/10.1016/j.medin.2020.06.016
doi: 10.1016/j.medin.2020.06.016
Baker SP, O'Neill B, Haddon W Jr, Long WB (1974) The Injury Severity Score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma 14:187–196
doi: 10.1097/00005373-197403000-00001
Teasdale G, Jennett B (1974) Assessement of coma and impaired conciousness. A practical scale. Lancet. 2:81–84
doi: 10.1016/S0140-6736(74)91639-0
Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818–829
doi: 10.1097/00003246-198510000-00009
Marshall LF, Marshall SB, Klauber MR, Van Berkum CM, Eisenberg H, Jane JA, Luerssen TG, Marmarou A, Foulkes MA (1992) The diagnosis of head injury requires a classification based on computed axial tomography. J Neurotrauma 9(Suppl 1):S287–S292
pubmed: 1588618
Bao HJ, Wang T, Zhang MY, Liu R, Dai DK, Wang YQ, Wang L, Zhang L, Gao YZ, Qin ZH, Chen XP, Tao LY (2012) Poloxamer-188 attenuates TBI-induced blood-brain barrier damage leading to decreased brain edema and reduced cellular death. Neurochem Res 37:2856–2867
doi: 10.1007/s11064-012-0880-4