Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5'-nucleotidase/CD73 in the Rat Fetal Brain.
Antioxidant system
Ectonucleotidases
Glucocorticoids
Neurodevelopment
Oxidative stress
Purinergic signaling
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
20
11
2020
accepted:
13
03
2021
pubmed:
25
3
2021
medline:
1
7
2022
entrez:
24
3
2021
Statut:
ppublish
Résumé
Dexamethasone (DEX) is frequently used to treat women at risk of preterm delivery, but although indispensable for the completion of organ maturation in the fetus, antenatal DEX treatment may exert adverse sex-dimorphic neurodevelopmental effects. Literature findings implicated oxidative stress in adverse effects of DEX treatment. Purinergic signaling is involved in neurodevelopment and controlled by ectonucleotidases, among which in the brain the most abundant are ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1/CD39) and ecto-5'-nucleotidase (e5'NT/CD73), which jointly dephosphorylate ATP to adenosine. They are also involved in cell adhesion and migration, processes integral to brain development. Upregulation of CD39 and CD73 after DEX treatment was reported in adult rat hippocampus. We investigated the effects of maternal DEX treatment on CD39 and CD73 expression and enzymatic activity in the rat fetal brain of both sexes, in the context of oxidative status of the brain tissue. Fetuses were obtained at embryonic day (ED) 21, from Wistar rat dams treated with 0.5 mg DEX/kg/day, at ED 16, 17, and 18, and brains were processed and used for further analysis. Sex-specific increase in CD39 and CD73 expression and in the corresponding enzyme activities was induced in the brain of antenatally DEX-treated fetuses, more prominently in males. The oxidative stress induction after antenatal DEX treatment was confirmed in both sexes, although showing a slight bias in males. Due to the involvement of purinergic system in crucial neurodevelopmental processes, future investigations are needed to determine the role of these observed changes in the adverse effects of antenatal DEX treatment.
Identifiants
pubmed: 33761054
doi: 10.1007/s10571-021-01081-8
pii: 10.1007/s10571-021-01081-8
doi:
Substances chimiques
Antigens, CD
0
Dexamethasone
7S5I7G3JQL
5'-Nucleotidase
EC 3.1.3.5
Apyrase
EC 3.6.1.5
CD39 antigen
EC 3.6.1.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1965-1981Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (RS)
ID : 451-03-68/2020-14/200007
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 451-03-68/2020-14/ 200178
Organisme : University of Defense, Belgrade, RS
ID : MFVMA/04/19-21
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : NSERC; RGPIN-2016-05867
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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