Research on the medication rules of Chinese herbal formulas on treatment of threatened abortion.
Data mining
Prescription rules
TCM
Threatened abortion
Journal
Complementary therapies in clinical practice
ISSN: 1873-6947
Titre abrégé: Complement Ther Clin Pract
Pays: England
ID NLM: 101225531
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
30
09
2020
revised:
11
01
2021
accepted:
13
03
2021
pubmed:
25
3
2021
medline:
5
5
2021
entrez:
24
3
2021
Statut:
ppublish
Résumé
Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies. A variety of Chinese herbal medicines have shown good protective effects against TA. To analyze the different prescriptions for TA and summarize the medication rules for such treatment. Data mining methods including frequency analysis, cluster analysis, factor analysis and association rule learning were used in this study. In total, 171 herbs and 398 formulas were collected. The most frequently used herbs are Dipsaci Radix (Xuduan, accounts for 7.58%). The top three categories were deficiency-tonifying herbs (29.24%), wind-damp dispelling herbs (12.87%) and heat-clearing herbs (9.94%). Eleven factors and 8 clusters with clinical significance for prescription were formed by factor and cluster analyses. Tonification methods including spleen and kidney nourishment are the main principles for TA treatment and Shoutai Pill can be used as the basic formula for clinical addition or subtraction.
Sections du résumé
BACKGROUNDS
BACKGROUND
Threatened abortion (TA) is the most common complication during early pregnancy affecting 20%-25% pregnancies. A variety of Chinese herbal medicines have shown good protective effects against TA.
OBJECTIVE
OBJECTIVE
To analyze the different prescriptions for TA and summarize the medication rules for such treatment.
METHODS
METHODS
Data mining methods including frequency analysis, cluster analysis, factor analysis and association rule learning were used in this study.
RESULTS
RESULTS
In total, 171 herbs and 398 formulas were collected. The most frequently used herbs are Dipsaci Radix (Xuduan, accounts for 7.58%). The top three categories were deficiency-tonifying herbs (29.24%), wind-damp dispelling herbs (12.87%) and heat-clearing herbs (9.94%). Eleven factors and 8 clusters with clinical significance for prescription were formed by factor and cluster analyses.
CONCLUSIONS
CONCLUSIONS
Tonification methods including spleen and kidney nourishment are the main principles for TA treatment and Shoutai Pill can be used as the basic formula for clinical addition or subtraction.
Identifiants
pubmed: 33761430
pii: S1744-3881(21)00070-0
doi: 10.1016/j.ctcp.2021.101371
pii:
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Review
Langues
eng
Pagination
101371Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.