How expectations of pain elicited by consciously and unconsciously perceived cues unfold over time.
Adult
Anticipation, Psychological
/ physiology
Conditioning, Psychological
/ physiology
Consciousness
/ physiology
Cues
Facial Recognition
/ physiology
Female
Gyrus Cinguli
/ physiology
Humans
Machine Learning
Magnetoencephalography
Male
Nociceptive Pain
/ physiopathology
Pain Perception
/ physiology
Prefrontal Cortex
/ physiology
Time Factors
Unconscious, Psychology
Young Adult
Conditioning
Conscious and unconscious
Expectation of pain
Machine learning
Neural dynamics
Temporal decoding
Temporal generalization
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 07 2021
15 07 2021
Historique:
received:
03
01
2021
revised:
10
03
2021
accepted:
14
03
2021
pubmed:
26
3
2021
medline:
26
10
2021
entrez:
25
3
2021
Statut:
ppublish
Résumé
Expectation can shape the perception of pain within a fraction of time, but little is known about how perceived expectation unfolds over time and modulates pain perception. Here, we combine magnetoencephalography (MEG) and machine learning approaches to track the neural dynamics of expectations of pain in healthy participants with both sexes. We found that the expectation of pain, as conditioned by facial cues, can be decoded from MEG as early as 150 ms and up to 1100 ms after cue onset, but decoding expectation elicited by unconsciously perceived cues requires more time and decays faster compared to consciously perceived ones. Also, results from temporal generalization suggest that neural dynamics of decoding cue-based expectation were predominately sustained during cue presentation but transient after cue presentation. Finally, although decoding expectation elicited by consciously perceived cues were based on a series of time-restricted brain regions during cue presentation, decoding relied on the medial prefrontal cortex and anterior cingulate cortex after cue presentation for both consciously and unconsciously perceived cues. These findings reveal the conscious and unconscious processing of expectation during pain anticipation and may shed light on enhancing clinical care by demonstrating the impact of expectation cues.
Identifiants
pubmed: 33762214
pii: S1053-8119(21)00262-7
doi: 10.1016/j.neuroimage.2021.117985
pmc: PMC8248481
mid: NIHMS1715918
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
117985Subventions
Organisme : NCCIH NIH HHS
ID : R21 AT008707
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest All authors declare no conflicts of interest.
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