Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities.

To evaluate the short term associations between nitrogen dioxide (NO Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. 398 cities in 22 low to high income countries/regions. Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. On average, a 10 μg/m This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO

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Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: support from the National Natural Science Foundation of China, China Medical Board Collaborating Program, Medical Research Council, UK, Natural Environment Research Council, UK, European Union’s Horizon 2020 Project Exhaustion, Spanish Ministry of Science and Innovation, German Federal Ministry of Education and Research, the Environmental Restoration and Conservation Agency, Japan, the Czech Science Foundation, the Shanghai Municipal Science and Technology Commission, the Australian National Health and Medical Research Council, and the Academy of Finland; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.