De novo ATP1A3 variants cause polymicrogyria.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
03 2021
Historique:
received: 09 06 2020
accepted: 04 02 2021
entrez: 25 3 2021
pubmed: 26 3 2021
medline: 26 3 2021
Statut: epublish

Résumé

Polymicrogyria is a common malformation of cortical development whose etiology remains elusive. We conducted whole-exome sequencing for 124 patients with polymicrogyria and identified de novo

Identifiants

pubmed: 33762331
pii: 7/13/eabd2368
doi: 10.1126/sciadv.abd2368
pmc: PMC7990330
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Satoko Miyatake (S)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.
Clinical Genetics Department, Yokohama City University Hospital, Yokohama, Kanagawa 236-0004, Japan.

Mitsuhiro Kato (M)

Department of Pediatrics, Showa University School of Medicine, Tokyo 142-8666, Japan.

Takuma Kumamoto (T)

Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

Tomonori Hirose (T)

Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Eriko Koshimizu (E)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Takaaki Matsui (T)

Gene Regulation Research, Nara Institute of Science and Technology, Ikoma, Nara 630-0101, Japan.

Hideyuki Takeuchi (H)

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Hiroshi Doi (H)

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Keisuke Hamada (K)

Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Mitsuko Nakashima (M)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.
Department of Biochemistry, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.

Kazunori Sasaki (K)

Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Akio Yamashita (A)

Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Atsushi Takata (A)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.
Laboratory for Molecular Pathology of Psychiatric Disorders, RIKEN Center for Brain Science, Wako, Saitama 351-0198, Japan.

Kohei Hamanaka (K)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Mai Satoh (M)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Takabumi Miyama (T)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Yuri Sonoda (Y)

Department of Pediatrics, Kyushu University, Fukuoka 812-8582, Japan.

Momoko Sasazuki (M)

Department of Pediatrics, Kyushu University, Fukuoka 812-8582, Japan.

Hiroyuki Torisu (H)

Department of Pediatrics, Kyushu University, Fukuoka 812-8582, Japan.
Section of Pediatrics, Department of Medicine, Fukuoka Dental College, Fukuoka 814-0193, Japan.

Toshiro Hara (T)

Department of Pediatrics, Kyushu University, Fukuoka 812-8582, Japan.
Fukuoka Children's Hospital, Fukuoka 813-0017, Japan.

Yasunari Sakai (Y)

Department of Pediatrics, Kyushu University, Fukuoka 812-8582, Japan.

Yushi Noguchi (Y)

Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.

Mazumi Miura (M)

Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.

Yoko Nishimura (Y)

Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.

Kazuyuki Nakamura (K)

Department of Pediatrics, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan.

Hideyuki Asai (H)

Department of Pediatrics, Showa University School of Medicine, Tokyo 142-8666, Japan.

Nodoka Hinokuma (N)

Department of Pediatrics, Showa University School of Medicine, Tokyo 142-8666, Japan.

Fuyuki Miya (F)

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Laboratory for Medical Science Mathematics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.

Tatsuhiko Tsunoda (T)

Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Laboratory for Medical Science Mathematics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.

Masami Togawa (M)

Department of Pediatrics, Tottori Prefectural Central Hospital, Tottori 680-0901, Japan.

Yukihiro Ikeda (Y)

Department of Neonatology, Japanese Red Cross Otsu Hospital, Otsu, Shiga 520-8511, Japan.

Nobusuke Kimura (N)

Department of Pediatrics, Naniwa Ikuno Hospital, Osaka, Shiga 556-0014, Japan.

Kaoru Amemiya (K)

Department of Pediatrics, Saiwai Kodomo Clinic, Tachikawa 190-0002, Japan.

Asako Horino (A)

Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-8688, Japan.

Masataka Fukuoka (M)

Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-8688, Japan.

Hiroko Ikeda (H)

Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-8688, Japan.

Goni Merhav (G)

Radiology Department, Rambam Health Care Campus, Haifa 3109601, Israel.

Nina Ekhilevitch (N)

The Genetics Institute, Rambam Health Care Campus, Haifa 3109601, Israel.

Masaki Miura (M)

Department of Pediatrics, Nagaoka Red Cross Hospital, Nagaoka, Niigata 940-2085, Japan.

Takeshi Mizuguchi (T)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Noriko Miyake (N)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Atsushi Suzuki (A)

Molecular Cellular Biology Laboratory, Yokohama City University Graduate School of Medical Life Science, Yokohama, Kanagawa 236-0004, Japan.

Shouichi Ohga (S)

Department of Pediatrics, Kyushu University, Fukuoka 812-8582, Japan.

Hirotomo Saitsu (H)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.
Department of Biochemistry, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.

Hidehisa Takahashi (H)

Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Fumiaki Tanaka (F)

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Kazuhiro Ogata (K)

Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Chiaki Ohtaka-Maruyama (C)

Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

Naomichi Matsumoto (N)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan. naomat@yokohama-cu.ac.jp.

Classifications MeSH