Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
09
08
2020
accepted:
04
02
2021
entrez:
25
3
2021
pubmed:
26
3
2021
medline:
19
4
2022
Statut:
epublish
Résumé
Circulating levels of the adipokine leptin are linked to neuropathology in experimental cerebral malaria (ECM), but its source and regulation mechanism remain unknown. Here, we show that sequestration of infected red blood cells (iRBCs) in white adipose tissue (WAT) microvasculature increased local vascular permeability and leptin production. Mice infected with parasite strains that fail to sequester in WAT displayed reduced leptin production and protection from ECM. WAT sequestration and leptin induction were lost in CD36KO mice; however, ECM susceptibility revealed sexual dimorphism. Adipocyte leptin was regulated by the mechanistic target of rapamycin complex 1 (mTORC1) and blocked by rapamycin. In humans, although
Identifiants
pubmed: 33762334
pii: 7/13/eabe2484
doi: 10.1126/sciadv.abe2484
pmc: PMC7990332
pii:
doi:
Substances chimiques
Leptin
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI034969
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS055349
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007637
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Références
Nature. 1989 Sep 7;341(6237):57-9
pubmed: 2475784
J Infect Dis. 2003 Feb 1;187(3):461-6
pubmed: 12552430
Sci Signal. 2009 May 26;2(72):re3
pubmed: 19471024
Curr Opin Microbiol. 2006 Aug;9(4):374-80
pubmed: 16814594
Parasitol Today. 1994 Oct;10(10):410-2
pubmed: 15275552
Trends Immunol. 2010 Jun;31(6):228-35
pubmed: 20434953
Am J Trop Med Hyg. 1997 Oct;57(4):389-98
pubmed: 9347951
Trends Parasitol. 2017 Apr;33(4):276-284
pubmed: 28007406
Malar J. 2008 Dec 04;7:250
pubmed: 19055786
PLoS Pathog. 2008 May 16;4(5):e1000068
pubmed: 18483551
J Exp Med. 1990 Nov 1;172(5):1287-91
pubmed: 2230643
Curr Immunol Rev. 2008 May 1;4(2):70-79
pubmed: 20198122
Cell. 2015 Sep 24;163(1):84-94
pubmed: 26406372
Nat Med. 2004 Feb;10(2):143-5
pubmed: 14745442
Nat Commun. 2016 May 26;7:11659
pubmed: 27225796
Am J Hum Genet. 2007 Aug;81(2):234-42
pubmed: 17668374
Folia Parasitol (Praha). 2002;49(4):249-51
pubmed: 12641196
Immunol Rev. 2004 Oct;201:268-90
pubmed: 15361247
N Engl J Med. 2015 Mar 19;372(12):1126-37
pubmed: 25785970
Cell. 1995 Jul 14;82(1):101-10
pubmed: 7606775
Nature. 2000 Jun 29;405(6790):1015-6
pubmed: 10890433
PLoS Pathog. 2010 Sep 30;6(9):e1001032
pubmed: 20941396
Nature. 2003 Feb 20;421(6925):856-9
pubmed: 12594516
Trans R Soc Trop Med Hyg. 1969;63(2):198-202
pubmed: 4978466
Cell Metab. 2006 Jul;4(1):49-60
pubmed: 16814732
Mol Biochem Parasitol. 2009 Aug;166(2):99-108
pubmed: 19450727
Malar J. 2017 Nov 9;16(1):455
pubmed: 29121917
Front Cell Infect Microbiol. 2014 Aug 21;4:104
pubmed: 25191643
Immunol Rev. 1989 Dec;112:49-70
pubmed: 2575074
Am J Trop Med Hyg. 1990 Aug;43(2 Pt 2):30-7
pubmed: 2202227
Malar J. 2007 Mar 16;6:32
pubmed: 17367535
Infect Immun. 2013 Nov;81(11):3984-91
pubmed: 23940206
Cell Microbiol. 2011 Feb;13(2):198-209
pubmed: 21029292
Malar J. 2012 Jul 16;11:231
pubmed: 22799533
Diabetes. 2007 Jul;56(7):1872-80
pubmed: 17440173
Expert Rev Mol Med. 2009 May 26;11:e16
pubmed: 19467172
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11468-73
pubmed: 16051702
Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E322-30
pubmed: 12388166
Recent Prog Horm Res. 2004;59:305-31
pubmed: 14749508
Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1514-21
pubmed: 18689498
J Infect Dis. 2015 Oct 15;212(8):1317-21
pubmed: 25852120
J Infect Dis. 2006 Jul 15;194(2):208-5
pubmed: 16779727
Trans R Soc Trop Med Hyg. 2009 Jul;103(7):687-90
pubmed: 19136129
Horm Mol Biol Clin Investig. 2015 Feb;21(2):137-47
pubmed: 25719334
Am J Pathol. 2011 May;178(5):2146-58
pubmed: 21514429
Nat Commun. 2015 Jan 30;6:6050
pubmed: 25636003
FASEB J. 1999 Jul;13(10):1231-8
pubmed: 10385613
Nat Rev Immunol. 2006 Oct;6(10):772-83
pubmed: 16998510
Trends Parasitol. 2014 Sep;30(9):436-44
pubmed: 25113859
J Infect Dis. 1998 Oct;178(4):1225-7
pubmed: 9806067
Cytometry A. 2009 Mar;75(3):225-35
pubmed: 18785271
J Exp Med. 2012 Jan 16;209(1):93-107
pubmed: 22184632
Am J Trop Med Hyg. 2003 Oct;69(4):345-59
pubmed: 14640492
Malar J. 2017 May 3;16(1):185
pubmed: 28468674
mBio. 2015 Jun 02;6(3):e00725
pubmed: 26037126
Trends Parasitol. 2006 Nov;22(11):503-8
pubmed: 16979941
Lancet. 2001 May 12;357(9267):1502-3
pubmed: 11377606
Nature. 2013 Jun 27;498(7455):502-5
pubmed: 23739325
J Pharmacol Sci. 2009 Apr;109(4):496-503
pubmed: 19372632
J Clin Invest. 2018 Oct 1;128(10):4329-4342
pubmed: 30047927