Porcine Hemagglutinating Encephalomyelitis Virus Infection

CDCD (cesarean derived air-liquid interface respiratory epithelial cells betacoronavirus colostrum deprived) coronavirus infection neonatal pigs porcine hemagglutinating encephalomyelitis virus upper respiratory tract

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
24 05 2021
Historique:
received: 07 12 2020
accepted: 14 03 2021
pubmed: 26 3 2021
medline: 1 6 2021
entrez: 25 3 2021
Statut: epublish

Résumé

Porcine hemagglutinating encephalomyelitis virus (PHEV) is a betacoronavirus that causes vomiting and wasting disease and/or encephalomyelitis in suckling pigs. This study characterized PHEV infection, pathogenesis, and immune response in cesarean-derived, colostrum-deprived (CDCD) neonatal pigs. Infected animals developed mild respiratory, enteric, and neurological clinical signs between 2 to 13 days postoronasal inoculation (dpi). PHEV did not produce viremia, but virus shedding was detected in nasal secretions (1 to 10 dpi) and feces (2 to 7 dpi) by reverse transcriptase quantitative PCR (RT-qPCR). Viral RNA was detected in all tissues except liver, but the detection rate and RT-qPCR threshold cycle (

Identifiants

pubmed: 33762411
pii: JVI.02335-20
doi: 10.1128/JVI.02335-20
pmc: PMC8316118
pii:
doi:

Substances chimiques

Interferon-alpha 0
Interleukin-8 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 Mora-Díaz et al.

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Auteurs

Juan Carlos Mora-Díaz (JC)

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

Pablo E Piñeyro (PE)

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

Rolf Rauh (R)

Tetracore, Inc., Rockville, Maryland, USA.

William Nelson (W)

Tetracore, Inc., Rockville, Maryland, USA.

Zianab Sankoh (Z)

Tetracore, Inc., Rockville, Maryland, USA.

Edward Gregg (E)

Tetracore, Inc., Rockville, Maryland, USA.

José Antonio Carrillo-Ávila (JA)

Andalusian Public Health System Biobank, Granada, Spain.

Huigang Shen (H)

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

Rahul K Nelli (RK)

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

Jeffrey J Zimmerman (JJ)

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

Luis G Giménez-Lirola (LG)

Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA luisggl@iastate.edu.

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