The Role of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer.
colorectal cancer
perioperative chemotherapy
preoperative chemotherapy
staging
Journal
Cancer management and research
ISSN: 1179-1322
Titre abrégé: Cancer Manag Res
Pays: New Zealand
ID NLM: 101512700
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
11
2020
accepted:
14
02
2021
entrez:
25
3
2021
pubmed:
26
3
2021
medline:
26
3
2021
Statut:
epublish
Résumé
Neoadjuvant systemic therapy has many potential advantages over up-front surgery, including tumor downstaging, early treatment of micrometastatic disease, and providing an in vivo test of tumor biology. Due to these advantages, neoadjuvant therapy is becoming the standard of care for an increasing number of tumor types. Currently, colon cancer patients are still routinely treated with up-front surgery, and neoadjuvant systemic therapy is not yet standard. Limitations to widespread use of neoadjuvant therapy have included inaccurate radiological staging, concerns about tumor progression while undergoing preoperative treatment rendering a patient incurable, and a lack of randomized data demonstrating benefit. However, there is great interest in neoadjuvant chemotherapy, and a number of trials are under way. Early follow up of the first phase III trial of neoadjuvant chemotherapy for colon cancer demonstrated tumor downstaging and suggested an improvement in disease-free survival with neoadjuvant chemotherapy, and it is hoped that this will translate into longer-term overall survival benefit. Clinicians should closely watch this developing field, consider the option of neoadjuvant chemotherapy for colon cancer patients, and actively seek out opportunities for their patients to participate in ongoing clinical trials to further inform this field in future.
Identifiants
pubmed: 33762848
doi: 10.2147/CMAR.S262870
pii: 262870
pmc: PMC7982559
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2567-2579Informations de copyright
© 2021 Body et al.
Déclaration de conflit d'intérêts
Dr Ajay Raghunath reports a conference-travel grant from Amgen outside the submitted work. The authors report no other conflicts of interest in this work.
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