PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4

Animals CD4-Positive T-Lymphocytes / classification CRISPR-Cas Systems Cell Differentiation / immunology Class I Phosphatidylinositol 3-Kinases / genetics Gene Editing Gene Knockout Techniques Interleukin-2 / pharmacology Lymphocyte Activation / immunology Mice Mice, Inbred C57BL Multiprotein Complexes / biosynthesis Receptors, Antigen, T-Cell / genetics Signal Transduction Specific Pathogen-Free Organisms
CD4+ T cells CRISPR-Cas9 PI3K TCR signalling interactomics p110δ

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 19 11 2020
accepted: 02 02 2021
entrez: 25 3 2021
pubmed: 26 3 2021
medline: 16 9 2021
Statut: epublish

Résumé

Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP

Identifiants

DOI: 10.3389/fimmu.2021.631271 PMID: 33763075 PMC: PMC7982423
pubmed: 33763075
doi: 10.3389/fimmu.2021.631271
pmc: PMC7982423
doi:

Substances chimiques

Interleukin-2 0
Multiprotein Complexes 0
Receptors, Antigen, T-Cell 0
Class I Phosphatidylinositol 3-Kinases EC 2.7.1.137
Pik3cd protein, mouse EC 2.7.1.137

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

631271

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/B/000C0409
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/B/000L0799
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R000409/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/B/0000H235
Pays : United Kingdom

Informations de copyright

Copyright © 2021 Luff, Wojdyla, Oxley, Chessa, Hudson, Hawkins, Stephens, Barry and Okkenhaug.

Déclaration de conflit d'intérêts

STB and KH were employed by the company AstraZeneca. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Daisy H Luff (DH)

Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom.

Katarzyna Wojdyla (K)

Mass Spectrometry Facility, The Babraham Institute, Cambridge, United Kingdom.
Signalling Programme, The Babraham Institute, Cambridge, United Kingdom.

David Oxley (D)

Mass Spectrometry Facility, The Babraham Institute, Cambridge, United Kingdom.

Tamara Chessa (T)

Signalling Programme, The Babraham Institute, Cambridge, United Kingdom.

Kevin Hudson (K)

Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.

Phillip T Hawkins (PT)

Signalling Programme, The Babraham Institute, Cambridge, United Kingdom.

Len R Stephens (LR)

Signalling Programme, The Babraham Institute, Cambridge, United Kingdom.

Simon T Barry (ST)

Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.

Klaus Okkenhaug (K)

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol-4-phosphate 3-kinase › Phosphatidylinositol 3-kinases de classe I › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Interleukine-2 › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › PI3Kδ Forms Distinct Multiprotein Complexes at...
questionsmedicales.fr › Phénomènes microbiologiques › Axénie › Organismes exempts d'organismes pathogènes spécifiques › PI3Kδ Forms Distinct Multiprotein Complexes at...