Discovery of a Potent Conorfamide from
Journal
Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882
Informations de publication
Date de publication:
23 04 2021
23 04 2021
Historique:
pubmed:
26
3
2021
medline:
15
12
2021
entrez:
25
3
2021
Statut:
ppublish
Résumé
Natural products such as conotoxins have tremendous potential as tools for biomedical research and for the treatment of different human diseases. Conotoxins are peptides present in the venoms of predatory cone snails that have a rich diversity of pharmacological functions. One of the major bottlenecks in natural products research is the rapid identification and evaluation of bioactive molecules. To overcome this limitation, we designed a set of light-induced behavioral assays in zebrafish larvae to screen for bioactive conotoxins. We used this screening approach to test several unique conotoxins derived from different cone snail clades and discovered that a conorfamide from
Identifiants
pubmed: 33764053
doi: 10.1021/acs.jnatprod.0c01297
doi:
Substances chimiques
Mollusk Venoms
0
Neuropeptides
0
conorfamide
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1232-1243Subventions
Organisme : NIGMS NIH HHS
ID : P01 GM048677
Pays : United States
Organisme : CIHR
Pays : Canada