Hyperdense middle cerebral artery sign in large cerebral infarction.
atrial fibrillation3
computed tomography5
hemorrhagic transformation4
hyperdense middle cerebral artery sign1
large cerebral infarction2
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
23
02
2021
received:
31
12
2020
accepted:
03
03
2021
pubmed:
26
3
2021
medline:
1
7
2021
entrez:
25
3
2021
Statut:
ppublish
Résumé
To evaluate if the hyperdense middle cerebral artery sign (HMCAS) is an imaging biomarker for hemorrhagic transformation (HT) and the functional outcome of patients with large cerebral infarctions without thrombolytic therapy. The clinical and imaging data of 312 patients with large cerebral infarction without thrombolytic therapy were retrospectively analyzed. They were divided into patients who presented with HMCAS (n = 121) and those who did not (non-HMCAS[n = 168] patients), and the clinical data of the 2 groups were compared. This was a retrospective study. Of the 289 patients, 83(28.7%) developed HT. The incidence of atrial fibrillation, high homocysteine and admission NIHSS score at the time of admission was significantly higher in the HMCAS patients than in non-HMCAS patients (p < .05). The ASPECTS was significantly lower in HMCAS patients (t = -5.835, p < .001). The incidence of PH-2 and 3-month mRS score was also statistically significant higher in HMCAS patients (χ HMCAS in patients with a large cerebral infarction without thrombolytic therapy is an independent biomarker of HT. Length of HMCAS is also a marker of HT with lower ASPECTS in HMCAS patients.
Identifiants
pubmed: 33764692
doi: 10.1002/brb3.2116
pmc: PMC8119806
doi:
Substances chimiques
Fibrinolytic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e02116Informations de copyright
© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
Références
Cerebrovasc Brain Metab Rev. 1993 Spring;5(1):1-16
pubmed: 8452759
Acta Neurol Scand. 2021 Apr;143(4):355-366
pubmed: 33188539
Neurology. 2016 Jan 12;86(2):118-25
pubmed: 26658907
Curr Neurol Neurosci Rep. 2018 Sep 18;18(11):77
pubmed: 30229395
Cerebrovasc Dis. 2008;25(5):457-507
pubmed: 18477843
Stroke. 2010 Aug;41(8):1659-64
pubmed: 20595670
J Physiother. 2014 Mar;60(1):61
pubmed: 24856948
Neurol Neurochir Pol. 2017 Jan - Feb;51(1):33-37
pubmed: 28341040
J Neuroimaging. 2015 Mar-Apr;25(2):263-268
pubmed: 24707921
AJNR Am J Neuroradiol. 2012 Jan;33(1):90-6
pubmed: 22158924
N Engl J Med. 2013 Mar 7;368(10):893-903
pubmed: 23390923
J Cereb Blood Flow Metab. 2014 Feb;34(2):185-99
pubmed: 24281743
Stroke. 2019 Dec;50(12):e344-e418
pubmed: 31662037
Brain Behav. 2021 May;11(5):e02116
pubmed: 33764692
J Stroke Cerebrovasc Dis. 2004 Nov-Dec;13(6):235-46
pubmed: 17903981
Lancet Neurol. 2013 Jul;12(7):689-705
pubmed: 23726850
Lancet. 2007 Jan 27;369(9558):275-82
pubmed: 17258667
Stroke. 2010 Feb;41(2):288-94
pubmed: 20056933
Neurology. 2009 Jun 9;72(23):e116-7
pubmed: 19506216
Cerebrovasc Dis. 2008;26(2):126-33
pubmed: 18560215
AJNR Am J Neuroradiol. 2015 May;36(5):839-43
pubmed: 25634718
Br J Radiol. 2014 Aug;87(1040):20140216
pubmed: 24936980
Cerebrovasc Dis. 2000 Nov-Dec;10(6):419-23
pubmed: 11070370
N Engl J Med. 2015 Mar 12;372(11):1009-18
pubmed: 25671797
Cerebrovasc Dis. 2010;29(1):62-7
pubmed: 19907164
Lancet. 2000 May 13;355(9216):1670-4
pubmed: 10905241
N Engl J Med. 2013 Mar 7;368(10):914-23
pubmed: 23394476
AJNR Am J Neuroradiol. 1994 Jan;15(1):9-15; discussion 16-8
pubmed: 8141071
Cochrane Database Syst Rev. 2003;(3):CD000213
pubmed: 12917889
Cerebrovasc Dis. 2009;27(1):51-9
pubmed: 19018138
J Neurol Sci. 2017 May 15;376:112-116
pubmed: 28431593
JAMA Neurol. 2017 Apr 1;74(4):419-426
pubmed: 28241214
Neurocrit Care. 2015 Feb;22(1):146-64
pubmed: 25605626
Stroke. 1983 Sep-Oct;14(5):756-62
pubmed: 6658961
Lancet Neurol. 2012 Oct;11(10):860-7
pubmed: 22954705
Stroke. 2001 Jun;32(6):1330-5
pubmed: 11387495
Neurol India. 2009 Mar-Apr;57(2):143-50
pubmed: 19439843
Semin Ultrasound CT MR. 2005 Dec;26(6):394-403
pubmed: 16392660
N Engl J Med. 2008 Sep 25;359(13):1317-29
pubmed: 18815396