Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
COVID-19
/ blood
Cytokines
/ immunology
Humans
Inflammation
Longitudinal Studies
Lung
/ immunology
Macrophages
/ immunology
Middle Aged
Monocytes
/ immunology
Myeloid Cells
/ immunology
SARS-CoV-2
T-Lymphocytes
/ immunology
Transcriptome
Young Adult
ARDS
COVID-19
chemokines
coronavirus disease 2019
cytokines
lung immunity
macrophages
monocytes
single-cell RNA sequencing
tissue resident memory T cells
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
13 04 2021
13 04 2021
Historique:
received:
12
10
2020
revised:
27
01
2021
accepted:
05
03
2021
pubmed:
26
3
2021
medline:
24
4
2021
entrez:
25
3
2021
Statut:
ppublish
Résumé
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe manifestations have largely been studied in circulation. Here, we examined the relationship between immune processes in the respiratory tract and circulation through longitudinal phenotypic, transcriptomic, and cytokine profiling of paired airway and blood samples from patients with severe COVID-19 relative to heathy controls. In COVID-19 airways, T cells exhibited activated, tissue-resident, and protective profiles; higher T cell frequencies correlated with survival and younger age. Myeloid cells in COVID-19 airways featured hyperinflammatory signatures, and higher frequencies of these cells correlated with mortality and older age. In COVID-19 blood, aberrant CD163
Identifiants
pubmed: 33765436
pii: S1074-7613(21)00117-5
doi: 10.1016/j.immuni.2021.03.005
pmc: PMC7951561
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-814.e6Subventions
Organisme : NIAID NIH HHS
ID : U19 AI128949
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI093870
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK122130
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL145547
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI150680
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI141686
Pays : United States
Commentaires et corrections
Type : UpdateOf
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests J.Z., M.S., and S.M. have competing interests with IsoPlexis. The remaining authors declare no competing interests.
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