The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm.
COVID-19
Cytokine storm
Immunopathology
Lactoferrin
SARS-CoV-2
Journal
International immunopharmacology
ISSN: 1878-1705
Titre abrégé: Int Immunopharmacol
Pays: Netherlands
ID NLM: 100965259
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
05
02
2021
revised:
05
03
2021
accepted:
05
03
2021
pubmed:
26
3
2021
medline:
27
5
2021
entrez:
25
3
2021
Statut:
ppublish
Résumé
The COVID-19 pandemic is a serious global health threat caused by severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2). Symptoms of COVID-19 are highly variable with common hyperactivity of immune responses known as a "cytokine storm". In fact, this massive release of inflammatory cytokines into in the pulmonary alveolar structure is a main cause of mortality during COVID-19 infection. Current management of COVID-19 is supportive and there is no common clinical protocol applied to suppress this pathological state. Lactoferrin (LF), an iron binding protein, is a first line defense protein that is present in neutrophils and excretory fluids of all mammals, and is well recognized for its role in maturation and regulation of immune system function. Also, due to its ability to sequester free iron, LF is known to protect against insult-induced oxidative stress and subsequent "cytokine storm" that results in dramatic necrosis within the affected tissue. Review of the literature strongly suggests utility of LF to silence the "cytokine storm", giving credence to both prophylactic and therapeutic approaches towards combating COVID-19 infection.
Identifiants
pubmed: 33765614
pii: S1567-5769(21)00207-1
doi: 10.1016/j.intimp.2021.107571
pmc: PMC7953442
pii:
doi:
Substances chimiques
Cytokines
0
Lactoferrin
EC 3.4.21.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107571Subventions
Organisme : NIAID NIH HHS
ID : R42 AI117990
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
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