Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism.

Autism Spectrum Disorder / diagnostic imaging Autistic Disorder / diagnostic imaging Brain / diagnostic imaging Humans Magnetic Resonance Imaging Neurofeedback
autism spectrum disorder neurofeedback neurorehabilitation posterior superior temporal sulcus real-time functional magnetic resonance imaging social cognition

Journal

Autism : the international journal of research and practice
ISSN: 1461-7005
Titre abrégé: Autism
Pays: England
ID NLM: 9713494

Informations de publication

Date de publication:
08 2021
Historique:
pubmed: 27 3 2021
medline: 14 8 2021
entrez: 26 3 2021
Statut: ppublish

Résumé

Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits.

Identifiants

DOI: 10.1177/13623613211002052 PMID: 33765841
pubmed: 33765841
doi: 10.1177/13623613211002052
doi:

Types de publication

Clinical Trial, Phase II Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1746-1760

Auteurs

Bruno Direito (B)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.
ICNAS-Produção Unipessoal, Coimbra, Portugal.

Susana Mouga (S)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.
Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Alexandre Sayal (A)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.
ICNAS-Produção Unipessoal, Coimbra, Portugal.

Marco Simões (M)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.
Center for Informatics and Systems, University of Coimbra, Coimbra, Portugal.

Hugo Quental (H)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.
ICNAS-Produção Unipessoal, Coimbra, Portugal.

Inês Bernardino (I)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.

Rebecca Playle (R)

Cardiff University, Cardiff, Wales.

Rachel McNamara (R)

Cardiff University, Cardiff, Wales.

David Ej Linden (DE)

Cardiff University, Cardiff, Wales.
MHeNs, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, Netherlands.
ORCID: 0000-0002-5638-9292

Guiomar Oliveira (G)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.
Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
University Clinic of Pediatrics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Centro de Investigação e Formação Clínica, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Miguel Castelo Branco (M)

CNC.IBILI-Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
CIBIT, Coimbra Institute for Biomedical Imaging and Translational Research, ICNAS - Institute of Nuclear Sciences Applied to Health, University of Coimbra, Coimbra, Portugal.
ICNAS-Produção Unipessoal, Coimbra, Portugal.
ORCID: 0000-0003-4364-6373

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Training the social brain: Clinical and neural...
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Training the social brain: Clinical and neural...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Training the social brain: Clinical and neural...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Training the social brain: Clinical and neural...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Training the social brain: Clinical and neural...
questionsmedicales.fr › Disciplines et activités comportementales › Psychothérapie › Rétroaction psychologique › Rétroaction biologique (psychologie) › Rétroaction neurologique › Training the social brain: Clinical and neural...