The long shadow of childhood trauma for depression in midlife: examining daily psychological stress processes as a persistent risk pathway.

Childhood trauma daily diaries daily stress depression early life adversity persistent risk pathway stress appraisals

Journal

Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142

Informations de publication

Date de publication:
26 Mar 2021
Historique:
entrez: 26 3 2021
pubmed: 27 3 2021
medline: 27 3 2021
Statut: aheadofprint

Résumé

Childhood trauma (CT) increases the risk of adult depression. Buffering effects require an understanding of the underlying persistent risk pathways. This study examined whether daily psychological stress processes - how an individual interprets and affectively responds to minor everyday events - mediate the effect of CT on adult depressive symptoms. Middle-aged women (N = 183) reported CT at baseline and completed daily diaries of threat appraisals and negative evening affect for 7 days at baseline, 9, and 18 months. Depressive symptoms were measured across the 1.5-year period. Mediation was examined using multilevel structural equation modeling. Reported CT predicted greater depressive symptoms over the 1.5-year time period (estimate = 0.27, s.e. = 0.07, 95% CI 0.15-0.38, p < 0.001). Daily threat appraisals and negative affect mediated the effect of reported CT on depressive symptoms (estimate = 0.34, s.e. = 0.08, 95% CI 0.22-0.46, p < 0.001). Daily threat appraisals explained more than half of this effect (estimate = 0.19, s.e. = 0.07, 95% CI 0.08-0.30, p = 0.004). Post hoc analyses in individuals who reported at least moderate severity of CT showed that lower threat appraisals buffered depressive symptoms. A similar pattern was found in individuals who reported no/low severity of CT. A reported history of CT acts as a latent vulnerability, exaggerating threat appraisals of everyday events, which trigger greater negative evening affect - processes that have important mental health consequences and may provide malleable intervention targets.

Sections du résumé

BACKGROUND BACKGROUND
Childhood trauma (CT) increases the risk of adult depression. Buffering effects require an understanding of the underlying persistent risk pathways. This study examined whether daily psychological stress processes - how an individual interprets and affectively responds to minor everyday events - mediate the effect of CT on adult depressive symptoms.
METHODS METHODS
Middle-aged women (N = 183) reported CT at baseline and completed daily diaries of threat appraisals and negative evening affect for 7 days at baseline, 9, and 18 months. Depressive symptoms were measured across the 1.5-year period. Mediation was examined using multilevel structural equation modeling.
RESULTS RESULTS
Reported CT predicted greater depressive symptoms over the 1.5-year time period (estimate = 0.27, s.e. = 0.07, 95% CI 0.15-0.38, p < 0.001). Daily threat appraisals and negative affect mediated the effect of reported CT on depressive symptoms (estimate = 0.34, s.e. = 0.08, 95% CI 0.22-0.46, p < 0.001). Daily threat appraisals explained more than half of this effect (estimate = 0.19, s.e. = 0.07, 95% CI 0.08-0.30, p = 0.004). Post hoc analyses in individuals who reported at least moderate severity of CT showed that lower threat appraisals buffered depressive symptoms. A similar pattern was found in individuals who reported no/low severity of CT.
CONCLUSIONS CONCLUSIONS
A reported history of CT acts as a latent vulnerability, exaggerating threat appraisals of everyday events, which trigger greater negative evening affect - processes that have important mental health consequences and may provide malleable intervention targets.

Identifiants

pubmed: 33766171
doi: 10.1017/S0033291721000921
pii: S0033291721000921
pmc: PMC8647837
mid: NIHMS1712468
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-10

Subventions

Organisme : NIA NIH HHS
ID : K99 AG062778
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG062778
Pays : United States

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Auteurs

Stefanie E Mayer (SE)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.

Agus Surachman (A)

Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, USA.
Center for Healthy Aging, The Pennsylvania State University, University Park, PA, USA.

Aric A Prather (AA)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.

Eli Puterman (E)

School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.

Kevin L Delucchi (KL)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.

Michael R Irwin (MR)

Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.

Andrea Danese (A)

Social, Genetic and Developmental Psychiatry Centre and Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
National and Specialist CAMHS Clinic for Trauma, Anxiety, and Depression, South London and Maudsley NHS Foundation Trust, London, UK.

David M Almeida (DM)

Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, USA.
Center for Healthy Aging, The Pennsylvania State University, University Park, PA, USA.

Elissa S Epel (ES)

Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.

Classifications MeSH