A symphony of destruction: Dynamic differential fibrinogenolytic toxicity by rattlesnake (Crotalus and Sistrurus) venoms.
Blood
Coagulotoxicity
Evolution
Rattlesnakes
Snakebite
Venom
Journal
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
ISSN: 1532-0456
Titre abrégé: Comp Biochem Physiol C Toxicol Pharmacol
Pays: United States
ID NLM: 100959500
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
16
01
2021
revised:
02
03
2021
accepted:
15
03
2021
pubmed:
27
3
2021
medline:
1
9
2021
entrez:
26
3
2021
Statut:
ppublish
Résumé
What factors influence the evolution of a heavily selected functional trait in a diverse clade? This study adopts rattlesnakes as a model group to investigate the evolutionary history of venom coagulotoxicity in the wider context of phylogenetics, natural history, and biology. Venom-induced clotting of human plasma and fibrinogen was determined and mapped onto the rattlesnake phylogenetic tree to reconstruct the evolution of coagulotoxicity across the group. Our results indicate that venom phenotype is often independent of phylogenetic relationships in rattlesnakes, suggesting the importance of diet and/or other environmental variables in driving venom evolution. Moreover, the striking inter- and intraspecific variability in venom activity on human blood highlights the considerable variability faced by physicians treating envenomation. This study is the most comprehensive effort to date to describe and characterize the evolutionary and biological aspects of coagulotoxins in rattlesnake venom. Further research at finer taxonomic levels is recommended to elucidate patterns of variation within species and lineages.
Identifiants
pubmed: 33766656
pii: S1532-0456(21)00061-2
doi: 10.1016/j.cbpc.2021.109034
pmc: PMC8162888
mid: NIHMS1698402
pii:
doi:
Substances chimiques
Crotalid Venoms
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109034Subventions
Organisme : NIH HHS
ID : P40 OD010960
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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