OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement: Classification of Atrophy Meetings Report 6.

Choroid / diagnostic imaging Early Diagnosis Fluorescein Angiography / methods Fundus Oculi Geographic Atrophy / diagnosis Humans ROC Curve Retina / diagnostic imaging Tomography, Optical Coherence / methods Visual Acuity
Nascent geographic atrophy Outer retinal atrophy Reading center Retinal pigment epithelium Variability

Journal

Ophthalmology. Retina
ISSN: 2468-6530
Titre abrégé: Ophthalmol Retina
Pays: United States
ID NLM: 101695048

Informations de publication

Date de publication:
01 2022
Historique:
received: 17 02 2021
revised: 10 03 2021
accepted: 12 03 2021
pubmed: 27 3 2021
medline: 12 3 2022
entrez: 26 3 2021
Statut: ppublish

Résumé

To determine the interreader agreement for incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA) and their related features in age-related macular degeneration (AMD). Interreader agreement study. Twelve readers from 6 reading centers. After formal training, readers qualitatively assessed 60 OCT B-scans from 60 eyes with AMD for 9 individual features associated with early atrophy and performed 7 different annotations to quantify the spatial extent of OCT features within regions of interest. The qualitative and quantitative features were used to derive the presence of iRORA and cRORA and also in an exploratory analysis to examine if agreement could be improved using different combinations of features to define OCT atrophy. Interreader agreement based on Gwet's first-order agreement coefficient (AC Substantial or better interreader agreement was observed for all qualitatively graded OCT features associated with atrophy (AC Assessment of iRORA and cRORA, and most of their associated features, can be performed relatively consistently and robustly. A refined combination of features to define early atrophy could further improve interreader agreement.

Identifiants

DOI: 10.1016/j.oret.2021.03.008 PMID: 33766801
pubmed: 33766801
pii: S2468-6530(21)00093-2
doi: 10.1016/j.oret.2021.03.008
pii:
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4-14

Informations de copyright

Copyright © 2021 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Auteurs

Zhichao Wu (Z)

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.

Maximilian Pfau (M)

GRADE Reading Center and Department of Ophthalmology, University of Bonn, Bonn, Germany; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland.

Barbara A Blodi (BA)

Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Frank G Holz (FG)

GRADE Reading Center and Department of Ophthalmology, University of Bonn, Bonn, Germany.

Glenn J Jaffe (GJ)

DUKE Reading Center and Department of Ophthalmology, Duke University, Durham, North Carolina.

Sandra Liakopoulos (S)

Cologne Image Reading Center and Laboratory and Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Srinivas R Sadda (SR)

Doheny Imaging Reading Center and Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Giovanni Staurenghi (G)

Department of Biomedical and Clinical Science "Luigi Sacco," Luigi Sacco Hospital University of Milan, Milan, Italy.

Elvira Bjelopera (E)

Cologne Image Reading Center and Laboratory and Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Tyler Brown (T)

Utah Retinal Reading Center, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.

Petrus Chang (P)

GRADE Reading Center and Department of Ophthalmology, University of Bonn, Bonn, Germany.

John Choong (J)

DUKE Reading Center and Department of Ophthalmology, Duke University, Durham, North Carolina.

Giulia Corradetti (G)

Doheny Imaging Reading Center and Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Federico Corvi (F)

Doheny Imaging Reading Center and Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Amitha Domalpally (A)

Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Cynthia Hurtenbach (C)

Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Muneeswar Gupta Nittala (MG)

Doheny Imaging Reading Center and Doheny Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

Anthony Olson (A)

Utah Retinal Reading Center, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.

Jeong W Pak (JW)

Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Judith Pappe (J)

Cologne Image Reading Center and Laboratory and Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Marlene Saßmannshausen (M)

GRADE Reading Center and Department of Ophthalmology, University of Bonn, Bonn, Germany.

Cindy Skalak (C)

DUKE Reading Center and Department of Ophthalmology, Duke University, Durham, North Carolina.

Sarah Thiele (S)

GRADE Reading Center and Department of Ophthalmology, University of Bonn, Bonn, Germany.

Robyn H Guymer (RH)

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.

Steffen Schmitz-Valckenberg (S)

GRADE Reading Center and Department of Ophthalmology, University of Bonn, Bonn, Germany; Utah Retinal Reading Center, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah. Electronic address: steffen.valckenberg@utah.edu.

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Classifications MeSH

questionsmedicales.fr › Organes des sens › Oeil › Uvée › Choroïde › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Diagnostic › Diagnostic précoce › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic ophtalmologique › Angiographie fluorescéinique › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Fond de l'oeil › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Dégénérescence maculaire › Atrophie géographique › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Courbe ROC › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › OCT Signs of Early Atrophy in Age-Related...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Acuité visuelle › OCT Signs of Early Atrophy in Age-Related...