The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5.
Animals
B-Lymphocytes, Regulatory
/ immunology
Cell Survival
/ immunology
Cells, Cultured
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
/ immunology
Humans
Interleukin-10
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Multiple Sclerosis
/ immunology
Signaling Lymphocytic Activation Molecule Family
/ antagonists & inhibitors
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 03 2021
25 03 2021
Historique:
received:
17
04
2020
accepted:
01
03
2021
entrez:
26
3
2021
pubmed:
27
3
2021
medline:
10
4
2021
Statut:
epublish
Résumé
B cells have essential functions in multiple sclerosis and in its mouse model, experimental autoimmune encephalomyelitis, both as drivers and suppressors of the disease. The suppressive effects are driven by a regulatory B cell (Breg) population that functions, primarily but not exclusively, via the production of IL-10. However, the mechanisms modulating IL-10-producing Breg abundance are poorly understood. Here we identify SLAMF5 for controlling IL-10
Identifiants
pubmed: 33767202
doi: 10.1038/s41467-021-22230-z
pii: 10.1038/s41467-021-22230-z
pmc: PMC7994628
doi:
Substances chimiques
Cd84 protein, mouse
0
IL10 protein, mouse
0
Signaling Lymphocytic Activation Molecule Family
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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