Functions for Retinoic Acid-Related Orphan Receptor Alpha (RORα) in the Activation of Macrophages During Lipopolysaccharide-Induced Septic Shock.
Animals
Cells, Cultured
Chemokines
/ metabolism
Disease Models, Animal
Female
Inflammation
/ genetics
Lipopolysaccharides
/ adverse effects
Macrophage Activation
/ drug effects
Macrophages, Peritoneal
/ immunology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nuclear Receptor Subfamily 1, Group F, Member 1
/ antagonists & inhibitors
Shock, Septic
/ chemically induced
Signal Transduction
/ drug effects
Sulfonamides
/ administration & dosage
Thiophenes
/ administration & dosage
Treatment Outcome
LPS
RORA
inflammation
macrophage
mice
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
12
2020
accepted:
16
02
2021
entrez:
26
3
2021
pubmed:
27
3
2021
medline:
7
10
2021
Statut:
epublish
Résumé
The transcription factor Related Orphan Receptor Alpha (RORα) plays an important role in regulating circadian rhythm, inflammation, metabolism and cellular development. Herein we show that in the absence of functional RORα in mice there is reduced susceptibility to LPS-induced endotoxic shock, with selective decreases in release of pro-inflammatory cytokines. Treatment of mice with a RORα selective synthetic inhibitor also reduced the severity of LPS-induced endotoxemia. The reduction in responses in Rora deficient mice was associated with an alterations in metabolic and pro-inflammatory functions of macrophages, both
Identifiants
pubmed: 33767712
doi: 10.3389/fimmu.2021.647329
pmc: PMC7986717
doi:
Substances chimiques
Chemokines
0
Lipopolysaccharides
0
Nuclear Receptor Subfamily 1, Group F, Member 1
0
Rora protein, mouse
0
SR 3335
0
Sulfonamides
0
Thiophenes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
647329Informations de copyright
Copyright © 2021 Hams, Roberts, Bermingham and Fallon.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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