Exploring microRNA Signatures of DNA Damage Response Using an Innovative System of Genotoxic Stress in

DNA damage response NSC120686 camptothecin genotoxicity microRNA seedling development tyrosyl-DNA phosphodiesterase 1

Journal

Frontiers in plant science
ISSN: 1664-462X
Titre abrégé: Front Plant Sci
Pays: Switzerland
ID NLM: 101568200

Informations de publication

Date de publication:
2021
Historique:
received: 22 12 2020
accepted: 15 02 2021
entrez: 26 3 2021
pubmed: 27 3 2021
medline: 27 3 2021
Statut: epublish

Résumé

One of the challenges that living organisms face is to promptly respond to genotoxic stress to avoid DNA damage. To this purpose, all organisms, including plants, developed complex DNA damage response (DDR) mechanisms. These mechanisms are highly conserved among organisms and need to be finely regulated. In this scenario, microRNAs (miRNAs) are emerging as active players, thus attracting the attention of the research community. The involvement of miRNAs in DDR has been investigated prominently in human cells whereas studies in plants are still scarce. To experimentally investigate the involvement of plant miRNAs in the regulation of DDR-associated pathways, an

Identifiants

pubmed: 33767724
doi: 10.3389/fpls.2021.645323
pmc: PMC7985446
doi:

Types de publication

Journal Article

Langues

eng

Pagination

645323

Informations de copyright

Copyright © 2021 Gualtieri, Gianella, Pagano, Cadeddu, Araújo, Balestrazzi and Macovei.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Carla Gualtieri (C)

Plant Biotechnology Laboratory, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Maraeva Gianella (M)

Plant Biotechnology Laboratory, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Andrea Pagano (A)

Plant Biotechnology Laboratory, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Tiziano Cadeddu (T)

Plant Biotechnology Laboratory, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Susana Araújo (S)

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Association BLC3, Technology and Innovation Campus, Centre BIO- R&D Unit, Lagares da Beira, Portugal.

Alma Balestrazzi (A)

Plant Biotechnology Laboratory, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Anca Macovei (A)

Plant Biotechnology Laboratory, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Classifications MeSH