Neurofibromatosis Type 1 with Highly Active Relapsing-Remitting Multiple Sclerosis (RRMS).
Multiple sclerosis
case report
natalizumab
neurofibromatosis 1
neurorehabilitation
Journal
European journal of case reports in internal medicine
ISSN: 2284-2594
Titre abrégé: Eur J Case Rep Intern Med
Pays: Italy
ID NLM: 101648453
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
12
2020
accepted:
23
12
2020
entrez:
26
3
2021
pubmed:
27
3
2021
medline:
27
3
2021
Statut:
epublish
Résumé
Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disease which confers an increased risk of malignant tumour development. Relapsing remitting multiple sclerosis (RRMS) is an inflammatory demyelinating disease of the central nervous system. The coexistence of multiple sclerosis and NF1 is rare but has been reported. Here, we describe the case of a 31-year-old man with NF1 and subacute walking problems with proximal pain in the lower limbs who was successfully treated with natalizumab. The coexistence of multiple sclerosis (MS) and neurofibromatosis type 1 (NF1) is very rare but has been described in the literature.Follow-up of patients with NF1 is important as the early detection and management of MS can prevent further disability.Appropriate treatment and physical therapy can improve the patient's activity and social life.
Identifiants
pubmed: 33768065
doi: 10.12890/2021_002190
pii: 2190-1-20031-1-10-20210201
pmc: PMC7977044
doi:
Types de publication
Journal Article
Langues
eng
Pagination
002190Informations de copyright
© EFIM 2021.
Déclaration de conflit d'intérêts
Conflicts of Interests: FC received travel grants and modest honoraria for membership of advisory boards from Almirall, Sanofi, Merck and Biogen
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