Galactorrhea during antipsychotic treatment: results from AMSP, a drug surveillance program, between 1993 and 2015.
AMSP program
Adverse drug reactions
Antipsychotic drugs
Galactorrhea
Psychiatric inpatients
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
12
10
2020
accepted:
12
02
2021
pubmed:
27
3
2021
medline:
19
2
2022
entrez:
26
3
2021
Statut:
ppublish
Résumé
Galactorrhea is a well-known adverse drug reaction (ADR) of numerous antipsychotic drugs (APD) and is often distressing for those affected. Methodological problems in the existing literature make it difficult to determine the prevalence of symptomatic hyperprolactinemia in persons treated with APDs. Consequently, a large sample of patients exposed to APDs is needed for more extensive evaluation. Data on APD utilization and reports of galactorrhea caused by APDs were analyzed using data from an observational pharmacovigilance program in German-speaking countries-Arzneimittelsicherheit in der Psychiatrie (AMSP)-from 1993 to 2015. 320,383 patients (175,884 female inpatients) under surveillance were treated with APDs for schizophrenia and other indications. A total of 170 events of galactorrhea caused by APDs were identified (0.97 cases in 1000 female inpatient admissions). Most cases occurred during the reproductive age with the highest incidence among patients between 16 and 30 years (3.81 cases in 1000 inpatients). The APDs that were most frequently imputed alone for inducing galactorrhea were risperidone (52 cases and 0.19% of all exposed inpatients), amisulpride (30 resp. 0.48%), and olanzapine (13 resp. 0.05%). In three cases, quetiapine had a prominent role as a probable cause for galactorrhea. High dosages of the imputed APDs correlated with higher rates of galactorrhea. Galactorrhea is a severe and underestimated condition in psychopharmacology. While some APDs are more likely to cause galactorrhea, we identified a few unusual cases. This highlights the importance of alertness in clinical practice and of taking a patient's individual situation into consideration.
Identifiants
pubmed: 33768297
doi: 10.1007/s00406-021-01241-3
pii: 10.1007/s00406-021-01241-3
pmc: PMC8563638
doi:
Substances chimiques
Antipsychotic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1425-1435Informations de copyright
© 2021. The Author(s).
Références
J Endocrinol Invest. 2008 May;31(5):436-44
pubmed: 18560262
Genes Dev. 1997 Jan 15;11(2):167-78
pubmed: 9009200
Int J Psychiatry Med. 2007;37(3):275-8
pubmed: 18314855
Neuropsychobiology. 1990-1991;23(3):124-8
pubmed: 2098668
Psychosomatics. 1982 Sep;23(9):959-61
pubmed: 7146292
J Psychiatr Res. 1994 Sep-Oct;28(5):461-73
pubmed: 7897617
Ment Health Clin. 2016 Jun 29;6(4):185-190
pubmed: 29955468
Neuropeptides. 1992 Mar;21(3):183-91
pubmed: 1321364
Monogr Gesamtgeb Psychiatr Psychiatry Ser. 1988;46:1-220
pubmed: 2831451
Pharmacopsychiatry. 2004 Mar;37 Suppl 1:S84-8
pubmed: 15052519
Ther Clin Risk Manag. 2007 Oct;3(5):929-51
pubmed: 18473017
Psychiatr Danub. 2011 Mar;23(1):123-4
pubmed: 21448116
Neuroendocrinology. 2019;109(1):7-19
pubmed: 30889571
Neuro Endocrinol Lett. 2004 Dec;25(6):419-22
pubmed: 15665803
Encephale. 2014 Feb;40(1):86-94
pubmed: 23928066
Ther Adv Psychopharmacol. 2013 Dec;3(6):322-34
pubmed: 24294485
Pharmacopsychiatry. 2004 Mar;37 Suppl 1:S4-11
pubmed: 15052509
Indian J Psychiatry. 2008 Jan;50(1):54-6
pubmed: 19771309
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8):1495-9
pubmed: 20732372
Br J Clin Pharmacol. 1997 Sep;44(3):277-81
pubmed: 9296322
J Clin Diagn Res. 2016 Jun;10(6):VD01-VD02
pubmed: 27504388
Ann Med Psychol (Paris). 1994 Mar;152(3):161-71
pubmed: 8085710
Gen Hosp Psychiatry. 2013 Sep-Oct;35(5):576.e3-5
pubmed: 23260337
J Clin Psychopharmacol. 2002 Apr;22(2):109-14
pubmed: 11910254
Psychosomatics. 2014 Jan-Feb;55(1):29-36
pubmed: 24140188
Folia Psychiatr Neurol Jpn. 1983;37(1):33-6
pubmed: 6411540
J Clin Psychiatry. 2000;61 Suppl 3:10-5
pubmed: 10724128
Prim Care Companion CNS Disord. 2012;14(2):
pubmed: 22943024
BMC Psychiatry. 2013 Aug 22;13:214
pubmed: 23968123
World J Biol Psychiatry. 2019 Nov;20(9):732-741
pubmed: 30058414
Pharmacopsychiatry. 2005 Nov;38(6):326-7
pubmed: 16342006
Indian J Pharmacol. 2010 Oct;42(5):322-3
pubmed: 21206628
J Psychopharmacol. 2007 Sep;21(7):768-73
pubmed: 17606473
Pharmacotherapy. 2009 Jan;29(1):64-73
pubmed: 19113797