A review of the BCG vaccine and other approaches toward tuberculosis eradication.
BCG
TB Vaccines
Trained Immunity
Tuberculosis
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
03 08 2021
03 08 2021
Historique:
pubmed:
27
3
2021
medline:
14
10
2021
entrez:
26
3
2021
Statut:
ppublish
Résumé
Despite aggressive eradication efforts, Tuberculosis (TB) remains a global health burden, one that disproportionally affects poorer, less developed nations. The only vaccine approved for TB, the Bacillus of Calmette and Guérin (BCG) vaccine remains controversial because it's stated efficacy has been cited as anywhere from 0 to 80%. Nevertheless, there have been exciting discoveries about the mechanism of action of the BCG vaccine that suggests it has a role in immunization schedules today. We review recent data suggesting the vaccine imparts protection against both tuberculosis and non-tuberculosis pathogens via a newly discovered immune system called trained immunity. BCG's efficacy also appears to be tied to its affect on granulocytes at the epigenetic and hematopoietic stem cell levels, which we discuss in this article at length. We also write about how the different strains of the BCG vaccine elicit different immune responses, suggesting that certain BCG strains are more immunogenic than others. Finally, our review delves into how the current vaccine is being reformulated to be more efficacious, and track the development of the next generation vaccines against TB.
Identifiants
pubmed: 33769193
doi: 10.1080/21645515.2021.1885280
pmc: PMC8475575
doi:
Substances chimiques
BCG Vaccine
0
Tuberculosis Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2454-2470Subventions
Organisme : NHLBI NIH HHS
ID : R15 HL143545
Pays : United States
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