Sex differences in neural correlates of common psychopathological symptoms in early adolescence.

Humans Male Female Adolescent Sex Characteristics Attention Deficit Disorder with Hyperactivity / diagnostic imaging Psychopathology Brain / diagnostic imaging Gray Matter / diagnostic imaging Psychomotor Agitation Magnetic Resonance Imaging
Adolescence IMAGEN attention-deficit hyperactivity disorder externalizing symptoms grey matter internalizing symptoms psychopathology sex differences voxel-wise morphometry

Journal

Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142

Informations de publication

Date de publication:
10 2022
Historique:
pubmed: 27 3 2021
medline: 5 1 2023
entrez: 26 3 2021
Statut: ppublish

Résumé

Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence. Participants were 14 years of age and part of the IMAGEN study, a large ( We found a sex-by-hyperactivity/inattention interaction in four brain clusters: right temporoparietal-opercular region ( Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.

Sections du résumé

BACKGROUND
Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence.
METHODS
Participants were 14 years of age and part of the IMAGEN study, a large (
RESULTS
We found a sex-by-hyperactivity/inattention interaction in four brain clusters: right temporoparietal-opercular region (
CONCLUSIONS
Using a large, sex-balanced and community-based sample, our study lends support to the idea that externalizing symptoms of hyperactivity/inattention may be associated with different neural structures in male and female adolescents. The brain regions we report have been associated with a myriad of important cognitive functions, in particular, attention, cognitive and motor control, and timing, that are potentially relevant to understand the behavioural manifestations of hyperactive and inattentive symptoms. This study highlights the importance of considering sex in our efforts to uncover mechanisms underlying psychopathology during adolescence.

Identifiants

DOI: 10.1017/S0033291720005140 PMID: 33769238 PMC: PMC9693717
pubmed: 33769238
doi: 10.1017/S0033291720005140
pii: S0033291720005140
pmc: PMC9693717
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3086-3096

Subventions

Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : Medical Research Council
ID : MR/W002418/1
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-058-0009-RG-DESR-C0759
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N000390/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S020306/1
Pays : United Kingdom

Auteurs

Francesca Biondo (F)

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
ORCID: 0000-0001-9952-0249

Charlotte Nymberg Thunell (CN)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Swedish National Board of Health and Welfare, Socialstyrelsen, Stockholm, Sweden.

Bing Xu (B)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Congying Chu (C)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Tianye Jia (T)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Key Laboratory of Computational Neuroscience and Brain-inspired Intelligence, Fudan University, Ministry of Education, China.

Alex Ing (A)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Erin Burke Quinlan (EB)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Nicole Tay (N)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Tobias Banaschewski (T)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Arun L W Bokde (ALW)

Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Christian Büchel (C)

University Medical Centre Hamburg-Eppendorf, Germany.

Sylvane Desrivières (S)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Herta Flor (H)

Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Department of Psychology, School of Social Sciences, University of Mannheim, Germany.

Vincent Frouin (V)

NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.

Hugh Garavan (H)

Departments of Psychiatry and Psychology, University of Vermont, USA.

Penny Gowland (P)

Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, UK.

Andreas Heinz (A)

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Germany.

Bernd Ittermann (B)

Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Germany.

Jean-Luc Martinot (JL)

Institut National de la Santé et de la Recherche Médicale, INSERM U A10 'Trajectoires développementales en psychiatrie', Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif sur Yvette, France.

Hervé Lemaitre (H)

Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, CNRS UMR 5293, Université de Bordeaux, Centre Broca Nouvelle-Aquitaine, Bordeaux, France.

Frauke Nees (F)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.

Dimitri Papadopoulos Orfanos (DP)

NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.

Luise Poustka (L)

Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Germany.

Sabina Millenet (S)

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Juliane H Fröhner (JH)

Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Germany.

Michael N Smolka (MN)

Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Germany.

Henrik Walter (H)

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Germany.

Robert Whelan (R)

School of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.

Edward D Barker (ED)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.

Gunter Schumann (G)

Centre for Population Neuroscience and Stratified Medicine (PONS) and Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
PONS Research Group, Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin and Leibniz Institute for Neurobiology, Magdeburg, Germany, and Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, P.R. China.

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