Socioeconomic, comorbidity, lifestyle, and quality of life comparisons between chronic rhinosinusitis phenotypes.
Adolescent
Adult
Aged
Aged, 80 and over
Asthma
/ epidemiology
Case-Control Studies
Chronic Disease
/ epidemiology
Comorbidity
Female
Humans
Life Style
Male
Middle Aged
Pain Measurement
Phenotype
Prospective Studies
Quality of Life
Respiratory Tract Infections
/ epidemiology
Rhinitis
/ complications
Sinusitis
/ complications
Socioeconomic Factors
Surveys and Questionnaires
United Kingdom
/ epidemiology
Rhinosinusitis
comorbidity
lifestyle
quality of life
socioeconomic
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
11
02
2021
received:
18
12
2020
accepted:
12
03
2021
pubmed:
27
3
2021
medline:
2
10
2021
entrez:
26
3
2021
Statut:
ppublish
Résumé
Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory sinonasal disorders with key defining symptoms, but traditionally separated into phenotypes by clinical/endoscopic findings. It is not known whether the two phenotypes have differing socioeconomic, comorbidity, and lifestyle differences. This analysis of the Chronic Rhinosinusitis Epidemiology Study (CRES) database sought to analyze any key differences in the socioeconomic variables between those with CRS with nasal polyps (CRSwNPs) and those without nasal polyps (CRSsNPs). We also sought to analyze differences in comorbidities, lifestyle, and quality of life. Patients with a confirmed diagnosis of CRS in secondary and tertiary care outpatient settings in the UK were invited to participate in a questionnaire-based case-control study. Variables included demographics, socioeconomic factors, comorbidities, lifestyle factors, and health-related quality of life (HRQoL) (level 3 evidence). A total of 1204 patients' data were analyzed: 553 CRSsNP and 651 CRSwNP participants. The key socioeconomic variables did not demonstrate any notable differences, nor did lifestyle variables other than alcohol consumption being higher in those with CRSwNP (P = .032), but the latter was not significant after adjusting for age and sex. Aside from confirmation of asthma being more common in CRSwNP, it was notable that this group complained less of upper respiratory tract infections (URTIs), and CRSsNP participants showed evidence of worse HRQoL scores in respect of body pain (P = .001). Patients with CRSwNP experience higher rates of asthma and lower rates of URTIs; patients with CRSsNP have worse body pain scores. Otherwise, there are no demonstrable significant socioeconomic, comorbidity, lifestyle, or quality of life differences between the two phenotypes. 3 Laryngoscope, 131:2179-2186, 2021.
Sections du résumé
BACKGROUND
Chronic rhinosinusitis (CRS) is a heterogeneous group of inflammatory sinonasal disorders with key defining symptoms, but traditionally separated into phenotypes by clinical/endoscopic findings. It is not known whether the two phenotypes have differing socioeconomic, comorbidity, and lifestyle differences. This analysis of the Chronic Rhinosinusitis Epidemiology Study (CRES) database sought to analyze any key differences in the socioeconomic variables between those with CRS with nasal polyps (CRSwNPs) and those without nasal polyps (CRSsNPs). We also sought to analyze differences in comorbidities, lifestyle, and quality of life.
METHODS
Patients with a confirmed diagnosis of CRS in secondary and tertiary care outpatient settings in the UK were invited to participate in a questionnaire-based case-control study. Variables included demographics, socioeconomic factors, comorbidities, lifestyle factors, and health-related quality of life (HRQoL) (level 3 evidence).
RESULTS
A total of 1204 patients' data were analyzed: 553 CRSsNP and 651 CRSwNP participants. The key socioeconomic variables did not demonstrate any notable differences, nor did lifestyle variables other than alcohol consumption being higher in those with CRSwNP (P = .032), but the latter was not significant after adjusting for age and sex. Aside from confirmation of asthma being more common in CRSwNP, it was notable that this group complained less of upper respiratory tract infections (URTIs), and CRSsNP participants showed evidence of worse HRQoL scores in respect of body pain (P = .001).
CONCLUSIONS
Patients with CRSwNP experience higher rates of asthma and lower rates of URTIs; patients with CRSsNP have worse body pain scores. Otherwise, there are no demonstrable significant socioeconomic, comorbidity, lifestyle, or quality of life differences between the two phenotypes.
LEVEL OF EVIDENCE
3 Laryngoscope, 131:2179-2186, 2021.
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2179-2186Subventions
Organisme : Anthony Long Trust
ID : N/A
Organisme : Bernice Bibby Trust
Organisme : the James
Informations de copyright
© 2021 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.
Références
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 2020;58:1-464.
Philpott CM, Erskine S, Hopkins C, Kumar N, Anari S, Kara N. Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study. Respir Res 2018;19:129.
Rocha V, Soares S, Stringhini S, Fraga S. Socioeconomic circumstances and respiratory function from childhood to early adulthood: a systematic review and meta-analysis. BMJ Open 2019;9:e027528.
Masoompour SM, Mahdaviazad H, Ghayumi SMA. Asthma and its related socioeconomic factors: the shiraz adult respiratory disease study 2015. Clin Respir J 2018;12:2110-2116.
Philpott C, Erskine S, Hopkins C, Coombes E, Kara N, Sunkareneni V. A case-control study of medical, psychological and socio-economic factors influencing the severity of chronic rhinosinusitis. Rhinology 2016;54:134-140.
Geramas I, Terzakis D, Hatzimanolis E, Georgalas C. Social factors in the development of chronic Rhinosinusitis: a systematic review. Curr Allergy Asthma Rep 2018;18:7.
Hutson K, Clark A, Hopkins C, Ahmed S, Kumar N, Carrie S. Smoking as a modifying factor in chronic rhinosinusitis. JAMA Otolaryngol Head Neck Surg 2021;147:159-165.
Ahn J-C, Kim J-W, Lee CH, Rhee C-S. Prevalence and risk factors of chronic rhinosinusitus, allergic rhinitis, and nasal septal deviation: results of the Korean National Health and Nutrition Survey 2008-2012. JAMA Otolaryngol Head Neck Surg 2016;142:162-167.
Bergmark RW, Hoehle LP, Chyou D, Phillips KM, Caradonna DS, Gray ST. Association of socioeconomic status, race and insurance status with chronic rhinosinusitis patient-reported outcome measures. Otolaryngol Head Neck Surg 2018;158:571-579.
Erskine SE, Verkerk MM, Notley C, Williamson IG, Philpott CM. Chronic rhinosinusitis: patient experiences of primary and secondary care-a qualitative study. Clin Otolaryngol 2016;41:8-14.
Erskine S, Hopkins C, Kumar N, Wilson J, Clark A, Robertson A. A cross sectional analysis of a case-control study about quality of life in CRS in the UK; a comparison between CRS subtypes. Rhinology 2016;54:311-315.
Erskine SE, Hopkins C, Clark A, Anari, Kumar N, Robertson A. SNOT-22 in a control population. Clin Otolaryngol 2017;42:81-85.
Erskine S, Notley C, Wilson A, Philpott C. Managing chronic rhinosinusitis and respiratory disease: a qualitative study of triggers and interactions. J Asthma 2014;24:1-18.
Philpott C, Hopkins C, Erskine S, Kumar N, Robertson A, Farboud A. The burden of revision sinonasal surgery in the UK-data from the chronic rhinosinusitis epidemiology study (CRES): a cross-sectional study. BMJ Open 2015;2015:e006680.
Erskine SE, Hopkins C, Clark A, Anari S, Robertson A, Sunkaraneni S. Chronic rhinosinusitis and mood disturbance. Rhinology 2017;55:113-119.
Maniakas A, Desrosiers M, Asmar MH, Al Falasi M, Endam LM, Hopkins C. Eustachian tube symptoms are frequent in chronic rhinosinusitis and respond well to endoscopic sinus surgery. Rhinology 2018;56:118-121.
Philpott C, Erskine S, Smith R, Hopkins C, Kara N, Farboud A. Current use of baseline medical treatment in chronic rhinosinusitis: data from the National Chronic Rhinosinusitis Epidemiology Study (CRES). Clin Otolaryngol. 2018;43:509-524.
Philpott CM, Smith R, Davies-Husband CR, Erskine S, Clark A, Welch A. Exploring the association between ingestion of foods with higher potential salicylate content and symptom exacerbation in chronic rhinosinusitis. Data from the National Chronic Rhinosinusitis Epidemiology Study. Rhinology 2019;57:303-312.
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med 2007;147:573-577.
Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F. European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl 2012;23:1-298.
Health Survey for England. Available at: https://digital.nhs.uk/data-and-information/publications/statistical/health-survey-for-england/2018/health-survey-for-england-2018-data-tables
Hopkins C, Browne JP, Slack R, Lund V, Topham J, Reeves B. The national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis. Clin Otolaryngol 2006;31:390-398.
Zhang Y, Gevaert E, Lou H, Wang X, Zhang L, Bachert C. Chronic rhinosinusitis in Asia. J Allergy Clin Immun 2017;140:1230-1239.
Lu-Myers Y, Deal AM, Miller JD, Thorp BD, Sreenath SB, McClurg SM. Comparison of socioeconomic and demographic factors in patients with chronic rhinosinusitis and allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg 2015;153:137-143.
Beswick DM, Mace JC, Rudmik L, Soler ZM, Alt JA, Smith KA. Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis. Int Forum Allergy Rhinol 2019;9:231-239.
Wahid NW, Smith R, Clark A, Salam M, Philpott CM. The socioeconomic cost of chronic rhinosinusitis study. Rhinology 2020;58:112-125.
Wu D, Bleier BS, Wei Y. Current understanding of the acute exacerbation of chronic Rhinosinusitis. Front Cell Infect Microbiol 2019;9:415-415.
Phillips KM, Hoehle LP, Bergmark RW, Caradonna DS, Gray ST, Sedaghat AR. Acute exacerbations mediate quality of life impairment in chronic rhinosinusitis. J Allergy Clin Immunol Pract 2017;5:422-426.
Banoub RG, Phillips KM, Hoehle LP, Caradonna DS, Gray ST, Sedaghat AR. Relationship between chronic rhinosinusitis exacerbation frequency and asthma control. Laryngoscope 2018;128:1033-1038.
Yamasaki A, Hoehle LP, Phillips KM, Hoehle LP, Phillips KM, Feng AL, Campbell AP, Caradonna DS. Association between systemic antibiotic and corticosteroid use for chronic rhinosinusitis and quality of life. Laryngoscope 2018;128:37-42.
Hopkins C, Williamson E, Morris S, Clarke CS, Thomas M, Evans H. Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records. Rhinology 2019;57:420-429.
Talat R, Speth MM, Gengler I, Phillips KM, Caradonna DS, Gray ST. Chronic Rhinosinusitis patients with and without polyps experience different symptom perception and quality of life burdens. Am J Rhinol Allergy 2020;34:742-750.
Sin DD, Wells H, Svenson LW, Man SF. Asthma and COPD among aboriginals in Alberta, Canada. Chest 2002;121:1841-1846.
Corvalán C, Amigo H, Bustos P, Rona RJ. Socioeconomic risk factors for asthma in Chilean young adults. Am J Public Health 2005;95:1375-1381.
Ratageri VH, Kabra SK, Dwivedi SN, Seth V. Factors associated with severe asthma. Indian Pediatr 2000;37:1072-1082.