A role for Dynlt3 in melanosome movement, distribution, acidity and transfer.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
26 03 2021
26 03 2021
Historique:
received:
04
04
2020
accepted:
25
02
2021
entrez:
27
3
2021
pubmed:
28
3
2021
medline:
6
8
2021
Statut:
epublish
Résumé
Skin pigmentation is dependent on cellular processes including melanosome biogenesis, transport, maturation and transfer to keratinocytes. However, how the cells finely control these processes in space and time to ensure proper pigmentation remains unclear. Here, we show that a component of the cytoplasmic dynein complex, Dynlt3, is required for efficient melanosome transport, acidity and transfer. In Mus musculus melanocytes with decreased levels of Dynlt3, pigmented melanosomes undergo a more directional motion, leading to their peripheral location in the cell. Stage IV melanosomes are more acidic, but still heavily pigmented, resulting in a less efficient melanosome transfer. Finally, the level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signalling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
Identifiants
pubmed: 33772156
doi: 10.1038/s42003-021-01917-5
pii: 10.1038/s42003-021-01917-5
pmc: PMC7997999
doi:
Substances chimiques
DYNLT3 protein, mouse
EC 3.6.1.-
Dyneins
EC 3.6.4.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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