Patient-Specific Modelling of Blood Coagulation.
Blood coagulation
Blood flow
Reaction–diffusion waves
Thrombin generation curves
Treatment
Journal
Bulletin of mathematical biology
ISSN: 1522-9602
Titre abrégé: Bull Math Biol
Pays: United States
ID NLM: 0401404
Informations de publication
Date de publication:
27 03 2021
27 03 2021
Historique:
received:
09
10
2020
accepted:
12
03
2021
entrez:
27
3
2021
pubmed:
28
3
2021
medline:
29
10
2021
Statut:
epublish
Résumé
Blood coagulation represents one of the most studied processes in biomedical modelling. However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. Next, this model is used to study spatial distributions of blood factors and blood coagulation in flow, and to evaluate the results of medical treatment of blood coagulation disorders.
Identifiants
pubmed: 33772645
doi: 10.1007/s11538-021-00890-8
pii: 10.1007/s11538-021-00890-8
pmc: PMC7998098
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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