LSD and ketanserin and their impact on the human autonomic nervous system.
Adult
Antihypertensive Agents
/ pharmacology
Autonomic Nervous System
/ drug effects
Electrocardiography
Female
Hallucinogens
/ pharmacology
Healthy Volunteers
Heart Rate
/ physiology
Humans
Ketanserin
/ pharmacology
Lysergic Acid Diethylamide
/ pharmacology
Male
Surveys and Questionnaires
Young Adult
LSD
RCT
heart rate variability
ketanserin
Journal
Psychophysiology
ISSN: 1540-5958
Titre abrégé: Psychophysiology
Pays: United States
ID NLM: 0142657
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
revised:
23
01
2021
received:
07
10
2020
accepted:
15
02
2021
pubmed:
28
3
2021
medline:
3
2
2022
entrez:
27
3
2021
Statut:
ppublish
Résumé
The interest in lysergic acid diethylamide (LSD) has sparked again due to its supposed positive effects on psychopathological conditions. Yet, most research focuses on the actions of LSD on the central nervous system. The interaction with the autonomic nervous system (ANS) has been neglected so far. Therefore, the aim was to assess the effects of LSD and the serotonin 2A receptor antagonist ketanserin on the ANS as assessed by heart rate variability (HRV) measures and their correlation with subjective drug-induced effects in a randomized, placebo-controlled crossover trial. Thus, ANS activity was derived from electrocardiogram recordings after intake of placebo, LSD or ketanserin, and LSD by calculating R-peak-based measures of sympathetic and parasympathetic activity. Repeated measure ANOVA and partial correlation for HRV measures and subjective experience questionnaires were performed. LSD predominantly increased sympathetic activity, while ketanserin counteracted this effect on the ANS via an increase of parasympathetic tone. Sympathetic activity was positively and parasympathetic activity negatively associated with psychedelic effects of LSD. Furthermore, Placebo HRV measures predicted subjective experiences after LSD intake. The association between trait ANS activity and LSD-induced subjective experiences may serve as a candidate biomarker set for the effectiveness of LSD in the treatment of psychopathological conditions.
Substances chimiques
Antihypertensive Agents
0
Hallucinogens
0
Lysergic Acid Diethylamide
8NA5SWF92O
Ketanserin
97F9DE4CT4
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13822Informations de copyright
© 2021 Society for Psychophysiological Research.
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