Enucleation of recurrent central odontogenic fibroma and bone regeneration of the osseous defect with enamel matrix derivative and bone allograft: Case report with 5-year follow-up.
bone graft(s)
bone regeneration
histology
oral pathology
Journal
Clinical advances in periodontics
ISSN: 2163-0097
Titre abrégé: Clin Adv Periodontics
Pays: United States
ID NLM: 101597440
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
11
12
2020
accepted:
19
03
2021
medline:
19
6
2023
pubmed:
28
3
2021
entrez:
27
3
2021
Statut:
ppublish
Résumé
Odontogenic fibroma is a rare benign neoplasm of mature fibrous connective tissue with variable amounts of inactive-looking odontogenic epithelium. Few recurrences of central odontogenic fibroma (COF) have been reported in the literature. This manuscript reports the enucleation of a recurrent COF and bone regeneration of the osseous defect with enamel matrix derivative and bone allograft. A 28-year-old Asian female presented in 2015 with a palatal depression between #10 and 11. The patient previously had an odontogenic fibroma between #10 and 11 removed in 2008. Cone beam computed tomographic evaluation revealed a well-defined, multiloculated radiolucency centered between #10 and 11 that extended from #9-12, and from the alveolar crest to the anterior border and floor of the maxillary sinus. The lesion resulted in splaying of the roots of #10 and 11, external root resorption on #10, loss of crestal and palatal bone cortices, and thinning of labial cortex between #10 and 11. The patient was referred to an oral surgeon for biopsy, and the lesion was diagnosed as odontogenic fibroma. The lesion was enucleated. Enamel matrix derivative was applied to the affected teeth and defect, which was subsequently grafted with bone allograft. At the 5-year follow-up, bone was regenerated to the midroot of #10 and coronal third of #11, with reestablishment of crestal and palatal bone cortices. Enucleation of COF and regeneration of the osseous defect with enamel matrix derivative and bone allograft appear to be a viable treatment approach that allows for preservation of contiguous teeth. Why is this case new information? This appears to be the first publication to report on bone regeneration following enucleation of a recurrent odontogenic fibroma. What are the keys to successful management of this case? Graft material provided space maintenance and a scaffold for bone regeneration. What are the primary limitations to success in this case? Loss of the labial bone resulted in a through-and-through defect between 10 and 11 that limited the amount of vertical bone regeneration.
Substances chimiques
enamel matrix proteins
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-83Informations de copyright
© 2021 American Academy of Periodontology.
Références
Van Heerden WFP, Kusama K, Neville BW. Odontogenic fibroma. In El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, eds. WHO Classification of Head and Neck Tumors, 4th ed. Lyon, France: IARC; 2017:228.
Handlers JP, Abrams AM, Melrose RJ, Danforth R. Central odontogenic fibroma: clinicopathologic features of 19 cases and review of the literature. J Oral Maxillofac Surg. 1991;49:46-54.
Eversole LR. Odontogenic fibroma, including amyloid and ossifying variants. Head Neck Pathol. 2011;5:335-343.
Correa Pontes FS, Lacerda de Souza L, Paulade Paula L, de Melo Galvão Neto E, Silva Gonçalves PF, Rebelo Pontes HA. Central odontogenic fibroma: an updated systematic review of cases reported in the literature with emphasis on recurrence influencing factors. J Craniomaxillofac Surg. 2018;46:1753-1757.
Roza ALOC, Sousa EM, Leite AA, et al. Central odontogenic fibroma: an international multicentric study of 62 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;S2212-4403(20):31171-31178.
Heimdal A, Isacsson G, Nilsson L. Recurrent central odontogenic fibroma. Oral Surg Oral Med Oral Pathol. 1980;50:140-145.
Svirsky JA, Abbey LM, Kaugars GE. A clinical review of central odontogenic fibroma: with the addition of three new cases. J Oral Med. 1986;41:51-54.
Jones GM, Eveson JW, Shepherd JP. Central odontogenic fibroma. A report of two controversial cases illustrating diagnostic dilemmas. Br J Oral Maxillofac Surg. 1989;27:406-411.
Kinney LA, Bradford J, Cohen M, Glickman RS. The aggressive odontogenic fibroma: report of a case. J Oral Maxillofac Surg. 1993;51:321-324.
Melo AR, Santos Tde S, do Amaral MF, Albuquerque Dde P, Andrade ES. Recurrence of central odontogenic fibroma: a rare case. Gen Dent. 2011;59:e78-81.