Autoimmune encephalitis after Japanese encephalitis in children: A prospective study.
Anti-neuronal surface antibodies
Autoimmune encephalitis
Cytokines
Japanese encephalitis
Outcomes
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 May 2021
15 May 2021
Historique:
received:
29
11
2020
revised:
22
02
2021
accepted:
15
03
2021
pubmed:
28
3
2021
medline:
15
5
2021
entrez:
27
3
2021
Statut:
ppublish
Résumé
To explore anti-neuronal surface antibodies and identify associated serum predictors of autoimmune encephalitis after Japanese encephalitis (JE). This prospective study first detected anti-neuronal surface antibodies and cytokines in the serum and cerebrospinal fluid (CSF) of JE patients within one week of symptom onset. Anti-neuronal surface antibodies and cytokines in the serum were detected on day 21 post-JE. If the patients relapsed during the convalescent phase, we simultaneously detected JE virus RNA and cytokines in the CSF, as well as anti-neuronal surface antibodies in the serum and CSF. All 31 patients were negative for anti-neuronal surface antibodies at the onset of JE in the serum and CSF. During the convalescent phase, five patients developed autoimmune encephalitis (two had anti-N-methyl-d-aspartate receptor [NMDAR] antibodies, one had γ-aminobutyric acid-B receptor [GABA In addition to anti-NMDAR antibodies, anti-GABA
Identifiants
pubmed: 33773410
pii: S0022-510X(21)00087-3
doi: 10.1016/j.jns.2021.117394
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117394Informations de copyright
Copyright © 2021. Published by Elsevier B.V.