Immune responses and exacerbations in severe asthma.

Allergens / immunology Animals Asthma / diagnosis Cytokines / metabolism Disease Progression Disease Susceptibility / immunology Eosinophils / immunology Host-Pathogen Interactions / genetics Humans Immunity Immunization Neutrophils / immunology Organ Specificity / immunology Severity of Illness Index T-Lymphocyte Subsets / immunology

Journal

Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118

Informations de publication

Date de publication:
10 2021
Historique:
received: 11 02 2021
accepted: 05 03 2021
pubmed: 28 3 2021
medline: 11 3 2022
entrez: 27 3 2021
Statut: ppublish

Résumé

Asthma as a clinical entity manifests with a broad spectrum of disease severity. Unlike milder asthma, severe disease is poorly controlled by inhaled corticosteroids, the current standard of care. Transcriptomic data, along with patient characteristics and response to biologics show that though Type 2 (T2) immune response remains an integral feature of asthma, additional molecular and immunologic factors may play important roles in pathogenesis. Mechanisms of T2 development, cellular sources of T2 cytokines and their relationship to additional immune pathways concurrently activated may distinguish several different subphenotypes, and perhaps endotypes of asthma, with differential response to non-specific and targeted anti-inflammatory therapies. Recent data have also associated non-T2 cytokines derived from T cells, particularly IFN-γ, and epithelial mediators with severe asthma. These topics and their relationships to acute asthma exacerbations are discussed in this review.

Identifiants

DOI: 10.1016/j.coi.2021.03.004 PMID: 33773471 PMC: PMC8460694
pubmed: 33773471
pii: S0952-7915(21)00024-8
doi: 10.1016/j.coi.2021.03.004
pmc: PMC8460694
mid: NIHMS1687505
pii:
doi:

Substances chimiques

Allergens 0
Cytokines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-42

Subventions

Organisme : NHLBI NIH HHS
ID : F32 HL147415
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113956
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI106684
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI048927
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007563
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

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Auteurs

Matthew J Camiolo (MJ)

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Sagar L Kale (SL)

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Timothy B Oriss (TB)

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Marc Gauthier (M)

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Anuradha Ray (A)

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: raya@pitt.edu.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Eucaryotes › Animaux › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes éosinophiles › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Immune responses and exacerbations in severe asthma.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Immune responses and exacerbations in severe asthma.