Potential therapeutic agents to COVID-19: An update review on antiviral therapy, immunotherapy, and cell therapy.


Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 07 01 2021
revised: 10 03 2021
accepted: 14 03 2021
pubmed: 29 3 2021
medline: 27 4 2021
entrez: 28 3 2021
Statut: ppublish

Résumé

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2020 and coronavirus disease 19 (COVID-19) was later announced as pandemic by the World Health Organization (WHO). Since then, several studies have been conducted on the prevention and treatment of COVID-19 by potential vaccines and drugs. Although, the governments and global population have been attracted by some vaccine production projects, the presence of SARS-CoV-2-specific antiviral drugs would be an urge necessity in parallel with the efficient preventive vaccines. Various nonspecific drugs produced previously against other bacterial, viral, and parasite infections were recently evaluated for treating patients with COVID-19. In addition to therapeutic properties of these anti-COVID-19 compounds, some adverse effects were observed in different human organs as well. Not only several attentions were paid to antiviral therapy and treatment of COVID-19, but also nanomedicine, immunotherapy, and cell therapy were conducted against this viral infection. In this review study, we planned to introduce the present and potential future treatment strategies against COVID-19 and define the advantages and disadvantages of each treatment strategy.

Identifiants

pubmed: 33774315
pii: S0753-3322(21)00303-6
doi: 10.1016/j.biopha.2021.111518
pmc: PMC7962551
pii:
doi:

Substances chimiques

Antiviral Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111518

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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Auteurs

Mona Sadat Mirtaleb (MS)

Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161 Tehran, Iran. Electronic address: monabiotechmirtaleb@gmail.com.

Amir Hossein Mirtaleb (AH)

Department of Materials Science & Engineering, Faculty of Engineering & Technology, Tarbiat Modares University, PO Box 14115-143, Tehran, Iran. Electronic address: amirhossein.mirtaleb@gmail.com.

Hassan Nosrati (H)

Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. Electronic address: h.nosrati@clin.au.dk.

Jalal Heshmatnia (J)

Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: jalalheshmatnia@gmail.com.

Reza Falak (R)

Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran; Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: falak.r@iums.ac.ir.

Reza Zolfaghari Emameh (R)

Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), 14965/161 Tehran, Iran. Electronic address: zolfaghari@nigeb.ac.ir.

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