Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia.

Angiotensin II / pharmacology Angiotensin II Type 1 Receptor Blockers / pharmacology Angiotensins / blood Benzimidazoles / pharmacology Biphenyl Compounds / pharmacology Female Humans Leptin / metabolism Leucyl Aminopeptidase / metabolism Placenta / drug effects Pre-Eclampsia / metabolism Pregnancy Renin-Angiotensin System / drug effects Tetrazoles / pharmacology Uterine Artery / physiopathology Vascular Resistance / physiology
candesartan leptin oxygen respiration trophoblasts

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
05 05 2021
Historique:
pubmed: 30 3 2021
medline: 15 1 2022
entrez: 29 3 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.120.16425 PMID: 33775117
pubmed: 33775117
doi: 10.1161/HYPERTENSIONAHA.120.16425
doi:

Substances chimiques

Angiotensin II Type 1 Receptor Blockers 0
Angiotensins 0
Benzimidazoles 0
Biphenyl Compounds 0
Leptin 0
Tetrazoles 0
Angiotensin II 11128-99-7
Leucyl Aminopeptidase EC 3.4.11.1
candesartan S8Q36MD2XX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1723-1736

Subventions

Organisme : Austrian Science Fund FWF
ID : DOC 31
Pays : Austria
Organisme : British Heart Foundation
ID : FS/17/72/33181
Pays : United Kingdom

Auteurs

Olivia Nonn (O)

From the Division of Cell Biology, Histology and Embryology (O.N., A.E.-H., T.K., D.F., B.H., M.G.), Medical University of Graz, Austria.

Cornelius Fischer (C)

Berlin Institute of Systems Biology, Max Delbrueck Centre for Molecular Medicine in the Helmholtz Association, Germany (C.F., S.G.).

Sabrina Geisberger (S)

Berlin Institute of Systems Biology, Max Delbrueck Centre for Molecular Medicine in the Helmholtz Association, Germany (C.F., S.G.).
Experimental Clinical Research Centre, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association and Charité Berlin, Germany (S.G., R.D., F.H.).
DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany (S.G.).
Berlin Institute of Health (BIH), Berlin, Germany (S.G.).

Amin El-Heliebi (A)

From the Division of Cell Biology, Histology and Embryology (O.N., A.E.-H., T.K., D.F., B.H., M.G.), Medical University of Graz, Austria.

Thomas Kroneis (T)

From the Division of Cell Biology, Histology and Embryology (O.N., A.E.-H., T.K., D.F., B.H., M.G.), Medical University of Graz, Austria.

Désirée Forstner (D)

From the Division of Cell Biology, Histology and Embryology (O.N., A.E.-H., T.K., D.F., B.H., M.G.), Medical University of Graz, Austria.

Gernot Desoye (G)

Gottfried Schatz Research Centre and Department of Obstetrics and Gynecology (G.D., M.K., C.S., C.W.), Medical University of Graz, Austria.

Anne Cathrine Staff (AC)

Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway (A.C.S., M.S.).
Division of Obstetrics and Gynecology, Oslo University Hospital, Norway (A.C.S., M.S.).

Meryam Sugulle (M)

Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway (A.C.S., M.S.).
Division of Obstetrics and Gynecology, Oslo University Hospital, Norway (A.C.S., M.S.).

Ralf Dechend (R)

Experimental Clinical Research Centre, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association and Charité Berlin, Germany (S.G., R.D., F.H.).

Ulrich Pecks (U)

Division of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Kiel, Germany (U.P.).

Martina Kollmann (M)

Gottfried Schatz Research Centre and Department of Obstetrics and Gynecology (G.D., M.K., C.S., C.W.), Medical University of Graz, Austria.

Christina Stern (C)

Gottfried Schatz Research Centre and Department of Obstetrics and Gynecology (G.D., M.K., C.S., C.W.), Medical University of Graz, Austria.

Judith E Cartwright (JE)

Molecular and Clinical Sciences Research Institute, St George's, University of London, United Kingdom (J.E.C., G.S.W.).

Guy S Whitley (GS)

Molecular and Clinical Sciences Research Institute, St George's, University of London, United Kingdom (J.E.C., G.S.W.).

Basky Thilaganathan (B)

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, United Kingdom (B.T.).

Christian Wadsack (C)

Gottfried Schatz Research Centre and Department of Obstetrics and Gynecology (G.D., M.K., C.S., C.W.), Medical University of Graz, Austria.

Berthold Huppertz (B)

From the Division of Cell Biology, Histology and Embryology (O.N., A.E.-H., T.K., D.F., B.H., M.G.), Medical University of Graz, Austria.

Florian Herse (F)

Experimental Clinical Research Centre, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association and Charité Berlin, Germany (S.G., R.D., F.H.).

Martin Gauster (M)

From the Division of Cell Biology, Histology and Embryology (O.N., A.E.-H., T.K., D.F., B.H., M.G.), Medical University of Graz, Austria.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Angiotensine-II › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antagonistes des récepteurs aux angiotensines › Antagonistes du récepteur de type 1 de l'angiotensine-II › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Dérivés du biphényle › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Leptine › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Metalloproteases › Metalloexopeptidases › Leucyl Aminopeptidase › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Structures de l'embryon › Placenta › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Pré-éclampsie › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Système rénine-angiotensine › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Tétrazoles › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artère utérine › Maternal Angiotensin Increases Placental...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Résistance vasculaire › Maternal Angiotensin Increases Placental...