Mechanisms Underlying Vascular Endothelial Growth Factor Receptor Inhibition-Induced Hypertension: The HYPAZ Trial.

Adult Aged Aged, 80 and over Angiogenesis Inhibitors / administration & dosage Cardiac Output / drug effects Endothelium, Vascular / drug effects Female Hemodynamics / drug effects Humans Hypertension / chemically induced Indazoles / administration & dosage Male Middle Aged Neoplasms / drug therapy Pyrimidines / administration & dosage Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors Sulfonamides / administration & dosage Vascular Resistance / drug effects Vascular Stiffness / drug effects
acetylcholine cardiovascular disease hypertension microvascular rarefaction pazopanib

Journal

Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255

Informations de publication

Date de publication:
05 05 2021
Historique:
pubmed: 30 3 2021
medline: 15 1 2022
entrez: 29 3 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/HYPERTENSIONAHA.120.16454 PMID: 33775123 PMC: PMC7610566
pubmed: 33775123
doi: 10.1161/HYPERTENSIONAHA.120.16454
pmc: PMC7610566
mid: EMS117921
doi:

Substances chimiques

Angiogenesis Inhibitors 0
Indazoles 0
Pyrimidines 0
Sulfonamides 0
pazopanib 7RN5DR86CK
Receptors, Vascular Endothelial Growth Factor EC 2.7.10.1

Banques de données

ClinicalTrials.gov
['NCT01392352']

Types de publication

Clinical Trial, Phase II Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1591-1599

Subventions

Organisme : Wellcome Trust
ID : 100780
Pays : United Kingdom

Références

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Auteurs

Kaisa M Mäki-Petäjä (KM)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.

Adam McGeoch (A)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.

Lucy L Yang (LL)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.

Annette Hubsch (A)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.

Carmel M McEniery (CM)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.

Paul A R Meyer (PAR)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.
Department of Medical Ophthalmology (P.A.R.M.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom.

Fraz Mir (F)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.

Parag Gajendragadkar (P)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.

Nicola Ramenatte (N)

Cambridge Clinical Trials Unit (N.R., S.J.B., I.B.W., D.I.J., J.C.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom.

Gayathri Anandappa (G)

Department of Oncology (G.A., D.I.J.), University of Cambridge, United Kingdom.

Sara Santos Franco (S)

GlaxoSmithKline R&D Clinical Unit, Addenbrooke's Hospital, Cambridge, United Kingdom (S.S.F.).

Simon J Bond (SJ)

Cambridge Clinical Trials Unit (N.R., S.J.B., I.B.W., D.I.J., J.C.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom.

Carola-Bibiane Schönlieb (CB)

Department of Applied Mathematics and Theoretical Physics (C.-B.S.), University of Cambridge, United Kingdom.

Yoeri Boink (Y)

Department of Applied Mathematics (Y.B., C.B.), University of Twente, the Netherlands.
Multi-Modality Medical Imaging group, Technical Medical Centre (Y.B.), University of Twente, the Netherlands.

Christoph Brune (C)

Department of Applied Mathematics (Y.B., C.B.), University of Twente, the Netherlands.

Ian B Wilkinson (IB)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.
Cambridge Clinical Trials Unit (N.R., S.J.B., I.B.W., D.I.J., J.C.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom.

Duncan I Jodrell (DI)

Department of Oncology (G.A., D.I.J.), University of Cambridge, United Kingdom.
Cambridge Clinical Trials Unit (N.R., S.J.B., I.B.W., D.I.J., J.C.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom.

Joseph Cheriyan (J)

Division of Experimental Medicine and Immunotherapeutics (K.M.M.-P., A.M., L.L.Y., A.H., C.M.M., P.A.R.M., F.M., P.G., I.B.W., J.C.), University of Cambridge, United Kingdom.
Cambridge Clinical Trials Unit (N.R., S.J.B., I.B.W., D.I.J., J.C.), Cambridge University Hospitals NHS Foundation Trust, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs de l'angiogenèse › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Débit cardiaque › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indazoles › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Tumeurs › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance endothéliale vasculaire › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Résistance vasculaire › Mechanisms Underlying Vascular Endothelial...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Rigidité vasculaire › Mechanisms Underlying Vascular Endothelial...