Detection of cerebral reorganization associated with degenerative cervical myelopathy using diffusion spectral imaging (DSI).
Adult
Aged
Aged, 80 and over
Anisotropy
Brain
/ diagnostic imaging
Cervical Vertebrae
/ diagnostic imaging
Cross-Sectional Studies
Diffusion Tensor Imaging
/ methods
Female
Humans
Male
Middle Aged
Prospective Studies
Spinal Cord Compression
/ diagnostic imaging
Spinal Cord Diseases
/ complications
Spondylosis
/ complications
White Matter
/ diagnostic imaging
Cervical spondylosis
Degenerative cervical myelopathy
Diffusion spectral imaging
Journal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
21
04
2020
revised:
09
11
2020
accepted:
07
01
2021
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
1
6
2021
Statut:
ppublish
Résumé
Degenerative Cervical Myelopathy (DCM) is a spinal cord disorder that causes significant physical disabilities in older patients. While most DCM research focuses on the spinal cord, widespread reorganization of the brain may occur to compensate for functional impairment. This observational study used diffusion spectrum imaging (DSI) to examine reorganization of cerebral white matter associated with neurological impairment as measured by the modified Japanese Orthopedic Association (mJOA), and severity of neck disability as measured by the Neck Disability Index (NDI) score. A total of 47 patients were included in the cervical spondylosis (CS) cohort: 38 patients with DCM (mean mJOA = 14.6, and mean NDI = 12.0), and 9 neurologically asymptomatic patients with spinal cord compression (mJOA = 18, and mean NDI = 7.0). 28 healthy volunteers (HCs) served as the control group. Lower generalized fractional anisotropy (GFA) was observed throughout much of the brain in patients compared to HCs (p < 0.05). Fiber pathways associated with somatosensory functions, such as the corpus callosum and corona radiata, showed increased quantitative anisotropy (QA) in patients compared to HCs. Correlation analyses further suggested that structural connectivity was enhanced to compensate for neurological dysfunction within sensorimotor regions, where fibers such as the posterior corona radiata had NQA values that were negatively associated with mJOA (p = 0.0020, R
Identifiants
pubmed: 33775321
pii: S0967-5868(21)00018-7
doi: 10.1016/j.jocn.2021.01.011
pmc: PMC8007933
mid: NIHMS1664350
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
164-173Subventions
Organisme : NINDS NIH HHS
ID : R01 NS078494
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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