Leveraging VGLUT3 Functions to Untangle Brain Dysfunctions.

Brain / metabolism Brain Diseases Glutamic Acid Humans Vesicular Glutamate Transport Proteins / metabolism
VGLUT3 co-transmission pathophysiology pharmacology vesicular glutamate transporters vesicular synergy

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
06 2021
Historique:
received: 12 10 2020
revised: 07 03 2021
accepted: 08 03 2021
pubmed: 30 3 2021
medline: 1 9 2021
entrez: 29 3 2021
Statut: ppublish

Résumé

Vesicular glutamate transporters (VGLUTs) were long thought to be specific markers of glutamatergic excitatory transmission. The discovery, two decades ago, of the atypical VGLUT3 has thoroughly modified this oversimplified view. VGLUT3 is strategically expressed in discrete populations of glutamatergic, cholinergic, serotonergic, and even GABAergic neurons. Recent reports show the subtle, but critical, implications of VGLUT3-dependent glutamate co-transmission and its roles in the regulation of diverse brain functions and dysfunctions. Progress in the neuropharmacology of VGLUT3 could lead to decisive breakthroughs in the treatment of Parkinson's disease (PD), addiction, eating disorders, anxiety, presbycusis, or pain. This review summarizes recent findings on VGLUT3 and its vesicular underpinnings as well as on possible ways to target this atypical transporter for future therapeutic strategies.

Identifiants

DOI: 10.1016/j.tips.2021.03.003 PMID: 33775453
pubmed: 33775453
pii: S0165-6147(21)00050-X
doi: 10.1016/j.tips.2021.03.003
pii:
doi:

Substances chimiques

SLC17A8 protein, human 0
Vesicular Glutamate Transport Proteins 0
Glutamic Acid 3KX376GY7L

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

475-490

Informations de copyright

Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors have no interests to declare.

Auteurs

Mathieu Favier (M)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada.

Nicolas Pietrancosta (N)

Sorbonne Université, INSERM, CNRS, Neurosciences Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005 Paris, France; Laboratoire des Biomolécules, LBM, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France.

Salah El Mestikawy (S)

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada; Sorbonne Université, INSERM, CNRS, Neurosciences Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), 75005 Paris, France.

Giuseppe Gangarossa (G)

Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France. Electronic address: giuseppe.gangarossa@u-paris.fr.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Leveraging VGLUT3 Functions to Untangle Brain...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Leveraging VGLUT3 Functions to Untangle Brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Leveraging VGLUT3 Functions to Untangle Brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Leveraging VGLUT3 Functions to Untangle Brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs de neurotransmetteurs › Transporteurs vésiculaires des neurotransmetteurs › Transporteurs vésiculaires du glutamate › Leveraging VGLUT3 Functions to Untangle Brain...