Addition of Astatine-211-Labeled Anti-CD45 Antibody to TBI as Conditioning for DLA-Identical Marrow Transplantation: A Novel Strategy to Overcome Graft Rejection in a Canine Presensitization Model: "Radioimmunotherapy to Overcome Transfusion-Induced Sensitization".
Astatine-211
DLA-identical marrow transplantation
Graft rejection
Transfusion sensitized
Journal
Transplantation and cellular therapy
ISSN: 2666-6367
Titre abrégé: Transplant Cell Ther
Pays: United States
ID NLM: 101774629
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
08
10
2020
revised:
18
02
2021
accepted:
21
02
2021
pubmed:
30
3
2021
medline:
3
7
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
In a canine model of presensitization using donor blood transfusions, 100% of historical control dogs receiving 9.2 Gy total body irradiation (TBI) conditioning before dog leukocyte antigen (DLA)-identical marrow grafts had graft rejection. In this presensitization model, we investigated whether the addition of monoclonal antibody (mAb)-based targeted radioimmunotherapy (RIT) with astatine-211 (
Identifiants
pubmed: 33775618
pii: S2666-6367(21)00705-3
doi: 10.1016/j.jtct.2021.02.018
pmc: PMC8217096
mid: NIHMS1677979
pii:
doi:
Substances chimiques
Astatine-211
0
Astatine
XI595HAL7H
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
476.e1-476.e7Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL122173
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK106829
Pays : United States
Informations de copyright
Copyright © 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
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